Center for Advanced Research in Gastroenterology and Hepatology, Department of Internal Medicine II, Division of Gastroenterology and Hepatology, "Victor Babes" University of Medicine and Pharmacy Timisoara, Eftimie Murgu Sq. No. 2, 300041 Timisoara, Romania.
Department X, 2nd Surgical Clinic, Researching Future Chirurgie 2, "Victor Babes" University of Medicine and Pharmacy Timisoara, Eftimie Murgu Sq. No. 2, 300041 Timisoara, Romania.
Biomolecules. 2023 Oct 22;13(10):1558. doi: 10.3390/biom13101558.
Acute pancreatitis (AP) remains a challenging medical condition, where a deeper metabolic insight could pave the way for innovative treatments. This research harnessed serum metabolomics to discern potential diagnostic markers for AP and distinguish between its biliary (BAP) and alcohol-induced (AAP) forms. Leveraging high-performance liquid chromatography coupled with mass spectrometry, the metabolic signatures of 34 AP patients were contrasted against 26 healthy participants, and then between different etiologies of AP. The results identified metabolites primarily from glycerophospholipids, glycerolipids, fatty acyls, sterol lipids, and pteridines and derivative classes, with the Human Metabolome Database aiding in classification. Notably, these metabolites differentiated AP from healthy states with high AUROC values above 0.8. Another set of metabolites revealed differences between BAP and AAP, but these results were not as marked as the former. This lipidomic analysis provides an introduction to the metabolic landscape of acute pancreatitis, revealing changes in multiple lipid classes and metabolites and identifying these metabolites. Future research could add and discover new diagnostic biomarkers and therapeutic strategies enhancing the management of acute pancreatitis.
急性胰腺炎（AP）仍然是一种具有挑战性的医学病症，深入的代谢研究可能为创新治疗方法铺平道路。本研究利用血清代谢组学来识别 AP 的潜在诊断标志物，并区分其胆源性（BAP）和酒精性（AAP）形式。该研究利用高效液相色谱-质谱联用技术，对比了 34 名 AP 患者和 26 名健康参与者的代谢特征，然后比较了 AP 的不同病因。结果确定了主要来自甘油磷脂、甘油酯、脂肪酸酰基、固醇脂质和蝶呤及其衍生物类别的代谢物，人类代谢组数据库有助于分类。值得注意的是，这些代谢物具有较高的 AUROC 值（高于 0.8），能够将 AP 与健康状态区分开来。另一组代谢物揭示了 BAP 和 AAP 之间的差异，但不如前者明显。这项脂质组学分析为急性胰腺炎的代谢图谱提供了一个介绍，揭示了多种脂质类别的变化和代谢物的变化，并确定了这些代谢物。未来的研究可以添加和发现新的诊断生物标志物和治疗策略，以加强对急性胰腺炎的管理。
