Department of Integrated Traditional Chinese and Western Medicine, Sichuan Provincial Pancreatitis Centre and West China-Liverpool Biomedical Research Centre, West China Hospital/West China Medical School, Sichuan University, Chengdu 610041, China; West China-Washington Mitochondria and Metabolism Centre, Frontiers Science Center for Disease-related Molecular Network, West China Hospital/West China Medical School, Sichuan University, Chengdu 610041, China.
School of Biological Sciences, and Surgical and Translational Research Centre, The University of Auckland, Auckland 1023, New Zealand.
Biochim Biophys Acta Mol Basis Dis. 2021 Jul 1;1867(7):166123. doi: 10.1016/j.bbadis.2021.166123. Epub 2021 Mar 11.
Acute pancreatitis (AP) is one of the most common gastroenterological disorders requiring hospitalization and is associated with substantial morbidity and mortality. Metabolomics nowadays not only help us to understand cellular metabolism to a degree that was not previously obtainable, but also to reveal the importance of the metabolites in physiological control, disease onset and development. An in-depth understanding of metabolic phenotyping would be therefore crucial for accurate diagnosis, prognosis and precise treatment of AP. In this review, we summarized and addressed the metabolomics design and workflow in AP studies, as well as the results and analysis of the in-depth of research. Based on the metabolic profiling work in both clinical populations and experimental AP models, we described the metabolites with potential utility as biomarkers and the correlation between the altered metabolites and AP status. Moreover, the disturbed metabolic pathways correlated with biological function were discussed in the end. A practical understanding of current and emerging metabolomic approaches applicable to AP and use of the metabolite information presented will aid in designing robust metabolomics and biological experiments that result in identification of unique biomarkers and mechanisms, and ultimately enhanced clinical decision-making.
急性胰腺炎（AP）是最常见的需要住院治疗的胃肠病学疾病之一，与较高的发病率和死亡率相关。代谢组学不仅帮助我们在以前无法达到的程度上了解细胞代谢，而且还揭示了代谢物在生理控制、疾病发生和发展中的重要性。因此，深入了解代谢表型对于 AP 的准确诊断、预后和精确治疗至关重要。在这篇综述中，我们总结并讨论了 AP 研究中的代谢组学设计和工作流程，以及深入研究的结果和分析。基于临床人群和实验性 AP 模型中的代谢特征分析工作，我们描述了具有作为生物标志物的潜在应用价值的代谢物，以及改变的代谢物与 AP 状态之间的相关性。此外，最后还讨论了与生物学功能相关的紊乱代谢途径。对适用于 AP 的现有和新兴代谢组学方法的实际理解，以及对所呈现的代谢物信息的使用，将有助于设计稳健的代谢组学和生物学实验，从而确定独特的生物标志物和机制，并最终改善临床决策。
