School of Public Health, Ningxia Medical University, Yinchuan 750004, China.
Ningxia Key Laboratory of Environmental Factors and Chronic Disease Control, Yinchuan 750004, China.
Nutrients. 2023 Oct 19;15(20):4437. doi: 10.3390/nu15204437.
polysaccharides (LBPs) have been shown to exert an antiglycemic effect. Emerging evidence suggests that patients with hyperglycemia have a hypercontractility of duodenum, and targeting duodenal contraction of duodenum can be beneficial to glucose metabolism. However, it is unknown whether LBPs can improve glucose metabolism by regulating the hypercontractility of the duodenum. Our aim was to explore the effect of LBPs on duodenal contraction in prediabetic mice and also preliminarily investigate the mechanism. The results showed that LBPs improved glucose homeostasis by decreasing the duodenal amplitude of contraction rather than frequency. Moreover, LBPs ameliorated the gut microbiota composition and the levels of short-chain fatty acids, especially acetic acid, which might bind to the receptor on neurons to regulate the contraction of the duodenum. Acetic acid was hypothesized to play a key role in the above process. Then, acetic acid was determined to exert an antiglycemic effect as expected. In conclusion, LBPs may rely on acetic acid to regulate duodenal contraction to ameliorate glucose metabolism in prediabetic mice, which provides a new therapeutic strategy to treat dysglycemia.
多糖（LBPs）已被证明具有降血糖作用。新出现的证据表明，高血糖患者的十二指肠存在高收缩性，针对十二指肠收缩进行治疗可能有益于葡萄糖代谢。然而，尚不清楚 LBPs 是否可以通过调节十二指肠的高收缩性来改善葡萄糖代谢。我们的目的是探讨 LBPs 对糖尿病前期小鼠十二指肠收缩的影响，并初步探讨其机制。结果表明，LBPs 通过降低十二指肠收缩幅度而非频率来改善葡萄糖稳态。此外，LBPs 改善了肠道微生物群落组成和短链脂肪酸水平，特别是乙酸，它可能与神经元上的受体结合，调节十二指肠的收缩。乙酸被假设在上述过程中发挥关键作用。然后，正如预期的那样，乙酸被确定具有降血糖作用。总之，LBPs 可能依赖于乙酸来调节十二指肠收缩，从而改善糖尿病前期小鼠的葡萄糖代谢，为治疗糖代谢紊乱提供了一种新的治疗策略。
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