Nitti Paola, Narayanan Athira, Pellegrino Rebecca, Villani Stefania, Madaghiele Marta, Demitri Christian
Department of Engineering for Innovation, University of Salento, 73100 Lecce, Italy.
Bioengineering (Basel). 2023 Sep 25;10(10):1122. doi: 10.3390/bioengineering10101122.
The advancement achieved in Tissue Engineering is based on a careful and in-depth study of cell-tissue interactions. The choice of a specific biomaterial in Tissue Engineering is fundamental, as it represents an interface for adherent cells in the creation of a microenvironment suitable for cell growth and differentiation. The knowledge of the biochemical and biophysical properties of the extracellular matrix is a useful tool for the optimization of polymeric scaffolds. This review aims to analyse the chemical, physical, and biological parameters on which are possible to act in Tissue Engineering for the optimization of polymeric scaffolds and the most recent progress presented in this field, including the novelty in the modification of the scaffolds' bulk and surface from a chemical and physical point of view to improve cell-biomaterial interaction. Moreover, we underline how understanding the impact of scaffolds on cell fate is of paramount importance for the successful advancement of Tissue Engineering. Finally, we conclude by reporting the future perspectives in this field in continuous development.
组织工程领域所取得的进展是基于对细胞-组织相互作用的细致深入研究。在组织工程中选择特定的生物材料至关重要，因为它是在创建适合细胞生长和分化的微环境时，为贴壁细胞提供的一个界面。细胞外基质的生化和生物物理特性知识是优化聚合物支架的有用工具。本综述旨在分析在组织工程中可用于优化聚合物支架的化学、物理和生物学参数，以及该领域呈现的最新进展，包括从化学和物理角度对支架本体和表面进行改性以改善细胞-生物材料相互作用方面的创新。此外，我们强调了解支架对细胞命运的影响对于组织工程的成功推进至关重要。最后，我们通过报道该不断发展领域的未来前景来作总结。
