Wettrell G, Anehus S, Hattevig G, Kjellman B
Allergy. 1986 Aug;41(6):418-22. doi: 10.1111/j.1398-9995.1986.tb00321.x.
The effect of terbutaline sulphate in slow-release (SR) tablets (Bricanyl Depot), 5 mg twice daily, was compared with that of terbutaline sulphate in ordinary tablets (Bricanyl), 2.5 mg three times daily, in a double-blind, randomized, cross-over study during 2 consecutive weeks in 10 asthmatic children. Plasma concentrations and urinary excretion of terbutaline were measured at various times during both treatment periods. The SR tablets produced a higher mean plasma concentration in the morning and a smaller peak-trough variation over the day than the ordinary ones. No differences between the two treatments were observed concerning FEV1 (forced expiratory volume in 1 s). Tremor, measured with an opto-electronic tremorgraph, was about the same for two treatments and not significantly different from tremor seen in healthy children. The reported side effects were less frequent in the SR tablet period.
在一项针对10名哮喘儿童的双盲、随机、交叉研究中，连续两周比较了硫酸特布他林缓释片（博利康尼长效片）每日两次、每次5毫克与硫酸特布他林普通片（博利康尼）每日三次、每次2.5毫克的疗效。在两个治疗期的不同时间测量了特布他林的血浆浓度和尿排泄量。与普通片相比，缓释片在早晨产生的平均血浆浓度更高，且一天内的峰谷变化更小。两种治疗在第1秒用力呼气量（FEV1）方面未观察到差异。用光电震颤仪测量的震颤在两种治疗中大致相同，且与健康儿童的震颤无显著差异。在服用缓释片期间，报告的副作用较少。
