Foged N, Høst A, Ljungholm K
Allergy. 1985 Oct;40(7):497-500. doi: 10.1111/j.1398-9995.1985.tb00256.x.
Thirty children 8-13 years old, with perennial asthma and with a reversibility of greater than or equal to 20% in lung function (FEV1) were given a sustained-release preparation of terbutaline sulphate 5 mg twice a day and ordinary tablets 2.5 mg three times a day; each treatment lasted 1 week. The design of the study was double-blind, cross-over, with a randomized allocation of the drugs. Both drugs improved the lung function significantly. The children had significantly less coughing during the night when they took depot tablets than when they took ordinary tablets. The side effects were few with both treatments. Most of the patients preferred the depot tablets.
30名8至13岁的常年性哮喘患儿，其肺功能（第一秒用力呼气容积，FEV1）可逆性大于或等于20%，给予硫酸特布他林缓释制剂5毫克，每日两次，普通片剂2.5毫克，每日三次；每种治疗持续1周。该研究设计为双盲、交叉、随机分配药物。两种药物均显著改善了肺功能。患儿服用长效片时夜间咳嗽明显少于服用普通片时。两种治疗的副作用都很少。大多数患者更喜欢长效片。
