College of Pharmaceutical Sciences, Key Laboratory of Pharmaceutical Quality Control of Hebei Province, Key Laboratory of Medicinal Chemistry and Molecular Diagnostics of Education Ministry of China, Hebei University, Baoding 071002, People's Republic of China.
Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, Hainan Normal University, Haikou 571158, People's Republic of China.
J Nat Prod. 2022 Jul 22;85(7):1880-1885. doi: 10.1021/acs.jnatprod.2c00322. Epub 2022 Jun 21.
Oxalierpenes A and B ( and ), two unusual indole-diterpenoid derivatives, were obtained from the marine-derived fungus . The absolute configurations of and were elucidated by calculated TDDFT ECD and DP4plus methods. Oxalierpene A () represents the first indole-diterpenoid derivative with a five-membered ring of 4-hydroxy-5,5-dimethyldihydrofuran-3-one as a side chain. Oxalierpene B () has a unique 6/5/6/5/5/6/6/5/5 ring system. Compounds and showed antiviral activity against the H1N1 virus and respiratory syncytial virus (RSV), with IC values ranging from 2.8 to 9.4 μM.
Oxalierpenes A 和 B（和），两种不寻常的吲哚二萜衍生物，从海洋来源的真菌中获得。和的绝对构型通过计算 TDDFT ECD 和 DP4plus 方法阐明。Oxalierpene A () 代表第一个具有作为侧链的 4-羟基-5,5-二甲基二氢呋喃-3-酮五元环的吲哚二萜衍生物。Oxalierpene B () 具有独特的 6/5/6/5/5/6/6/5/5 环系统。化合物和对 H1N1 病毒和呼吸道合胞病毒 (RSV) 具有抗病毒活性，IC 值范围为 2.8 至 9.4 μM。
