7-甲氧基-13-去羟基鬼笔环肽：来自内生真菌Nb 19的新型吲哚二萜类化合物。
7-Methoxy-13-dehydroxypaxilline: New indole diterpenoid from an endophytic fungus sp. Nb 19.
作者信息
Yu Jing, Wang Jia-Peng, Liu Shi-Fang, Yin Cui-Yun, Tang De-Ying, Li Yi-Hang, Zhang Li-Xia
机构信息
Yunnan Key Laboratory of Southern Medicine Utilization, Yunnan Branch Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Jinghong, China.
Yunnan Provincial Key Laboratory of Entomological Biopharmaceutical, College of Pharmacy, Dali University, Yunnan Dali, China.
出版信息
Nat Prod Res. 2024 Jan-Feb;38(1):103-111. doi: 10.1080/14786419.2022.2107639. Epub 2022 Aug 5.
ABSTACTA chemical investigation of the endophyte sp. Nb 19, isolated from leaves of the traditionally medical plant (Nees) Bremek., yielded one new indole diterpenoid, 7-methoxy-13-dehydroxypaxilline () together with seven known metabolites (-). The obtained structure of compound was elucidated by its spectroscopic data. In addition, the absolute configuration of compound was confirmed by ECD for the first time. Compounds - were evaluated for antitumor activity against MCF-7, HepG2, and HCCC-9810 cell lines.
摘要
对从传统药用植物（Nees）Bremek.的叶子中分离得到的内生菌sp. Nb 19进行化学研究，得到了一种新的吲哚二萜类化合物，7-甲氧基-13-脱羟基鬼笔毒环肽（）以及七种已知代谢产物（-）。通过光谱数据阐明了化合物的结构。此外，首次通过电子圆二色光谱（ECD）确定了化合物的绝对构型。对化合物-针对MCF-7、HepG2和HCCC-9810细胞系的抗肿瘤活性进行了评估。
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