从 中分离得到的三萜和叶啉及其细胞毒性、光细胞毒性和光动力抗菌活性。
Triterpenes and Pheophorbides from and Their Cytotoxicity, Photocytotoxicity, and Photodynamic Antibacterial Activity.
机构信息
School of Chemistry & Chemical Engineering, Guangxi University, Nanning 530004, China.
Key Laboratory of Sugarcane Biotechnology and Genetic Improvement (Guangxi), Ministry of Agriculture & Rural Affairs, Guangxi Key Laboratory of Sugarcane Genetic Improvement, Sugarcane Research Institute, Guangxi Academy of Agricultural Sciences, Nanning 530004, China.
出版信息
Molecules. 2023 Oct 12;28(20):7058. doi: 10.3390/molecules28207058.
Phytochemical investigation of the leaves of S. Y. Liang et Q. D. Chen led to the isolation of ten undescribed compounds, including six new triterpenes (-) and four new pheophorbide-related compounds (-). Meanwhile, the cytotoxic activity of the six triterpenes against six cancer cell lines was evaluated by MTT assay. Compound showed potent cytotoxicity toward HepG2 cells with an IC value of 2.57 μM. Compounds and exhibited cytotoxicity against MDA-MB231 cells, with IC values of 11.31 and 5.52 μM, respectively. Additionally, the cytotoxicity of four new pheophorbides against these cancer cells was evaluated both in the presence and absence of light treatment. Compound exhibited exceptional photocytotoxicity against Hela, MCF-7, and A549 cells, with IC values of 0.43 μM, 0.28 μM, and 0.92 μM, respectively. Compound demonstrated significant photodynamic cytotoxic activity against BEL-7402 and HepG2 cells with IC values of 0.77 μM and 0.33 μM, respectively. The photodynamic antibacterial activity of - was also tested for , , , and under direct illumination. Compounds and exhibited sensitivity to and demonstrated a photodynamic antibacterial effect, with a MIC value of 0.625 μM.
对 S. Y. Liang 和 Q. D. Chen 的叶子进行植物化学研究，分离得到了十种未描述的化合物，包括六种新的三萜（-）和四种新的原卟啉相关化合物（-）。同时，通过 MTT 测定法评估了六种三萜对六种癌细胞系的细胞毒性。化合物 对 HepG2 细胞表现出强烈的细胞毒性，IC 值为 2.57 μM。化合物 和 对 MDA-MB231 细胞表现出细胞毒性，IC 值分别为 11.31 和 5.52 μM。此外，还评估了四种新原卟啉在有光和无光条件下对这些癌细胞的细胞毒性。化合物 对 Hela、MCF-7 和 A549 细胞表现出优异的光细胞毒性，IC 值分别为 0.43 μM、0.28 μM 和 0.92 μM。化合物 对 BEL-7402 和 HepG2 细胞表现出显著的光动力细胞毒性，IC 值分别为 0.77 μM 和 0.33 μM。还对 - 进行了直接光照下的 、 、 、 和 的光动力抗菌活性测试。化合物 和 对 和 表现出敏感性，并具有光动力抗菌作用，MIC 值为 0.625 μM。
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