Shanxi Center for Testing of Functional Agro-Products, Longcheng Campus, Shanxi Agricultural University, No. 79, Longcheng Street, Taiyuan 030031, China.
Molecules. 2023 Oct 17;28(20):7123. doi: 10.3390/molecules28207123.
Fenpyroximate is an efficient, broad-spectrum phenoxypyrazole acaricide which is used for controlling various mites. In this study, we measured the levels of terminal fenpyroximate residues in citrus fruits, and estimated the dietary intake risks posed by fenpyroximate. To this end, a QuEChERS analytical method was used in combination with ultra-high-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) to determine the residual levels of fenpyroximate and its Z-isomer (Z-fenpyroximate) in citrus fruits collected from 12 fields under good agricultural practices (GAPs). The average recoveries of fenpyroximate in whole fruits and citrus flesh were 104-110% and 92-109%, respectively, with corresponding RSDs of 1-4% and 1-3%. The average recoveries of Z-fenpyroximate were 104-113% and 90-91%, respectively, with RSDs of 1-2% in both cases. Each limit of quantification (LOQ) was 0.01 mg kg. Fifteen days after application with 56 mg kg, the terminal residues of fenpyroximate in whole fruits and citrus flesh were <0.010-0.18 mg kg and <0.010-0.063 mg kg, respectively; the corresponding values for total fenpyroximate (the sum of fenpyroximate and Z-fenpyroximate) were <0.020-0.19 and <0.020-0.053 mg kg. The levels of terminal fenpyroximate residues in citrus fruit were less than the maximum residue limits (MRLs) specified in all the existing international standards. In addition, the risk quotients RQ and RQ were both less than 100%, indicating that the long-term and short-term dietary intake risks posed to Chinese consumers by fenpyroximate in citrus fruit are both acceptable after a 15-day harvest interval.
烯丙菊酯是一种高效、广谱的苯氧吡唑类杀螨剂，用于防治多种螨虫。本研究测定了柑橘果实中烯丙菊酯的最终残留量，并评估了烯丙菊酯的膳食摄入风险。为此，采用 QuEChERS 分析方法结合超高效液相色谱-串联质谱法（UHPLC-MS/MS），对在良好农业规范（GAP）下的 12 个田间采集的柑橘果实中烯丙菊酯及其 Z-异构体（Z-烯丙菊酯）残留水平进行了测定。烯丙菊酯在整个果实和柑橘果肉中的平均回收率为 104%-110%和 92%-109%，相应的相对标准偏差（RSD）为 1%-4%和 1%-3%。Z-烯丙菊酯的平均回收率分别为 104%-113%和 90%-91%，RSD 均为 1%-2%。每个定量限（LOQ）为 0.01mg/kg。施药后 15 天，整个果实和柑橘果肉中烯丙菊酯的最终残留量均<0.010-0.18mg/kg 和<0.010-0.063mg/kg；总烯丙菊酯（烯丙菊酯和 Z-烯丙菊酯之和）的相应值均<0.020-0.19mg/kg 和<0.020-0.053mg/kg。柑橘果实中烯丙菊酯的最终残留量均低于所有现行国际标准规定的最大残留限量（MRLs）。此外，风险商（RQ）和短期风险商（RQ）均小于 100%，表明在 15 天的收获间隔后，中国消费者从柑橘中摄入烯丙菊酯的长期和短期膳食摄入风险均可以接受。
