Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA 30322, USA.
Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA 30322, USA.
Int J Mol Sci. 2023 Oct 12;24(20):15127. doi: 10.3390/ijms242015127.
Ferroptosis is an iron-dependent regulatory form of cell death characterized by the accumulation of intracellular reactive oxygen species and lipid peroxidation. It plays a critical role not only in promoting drug resistance in tumors, but also in shaping therapeutic approaches for various malignancies. This review aims to elucidate the relationship between ferroptosis and head and neck cancer treatment by discussing its conceptual framework, mechanism of action, functional aspects, and implications for tumor therapy. In addition, this review consolidates strategies aimed at improving the efficacy of head and neck cancer treatment through modulation of ferroptosis, herein serving as a valuable reference for advancing the treatment landscape for this patient population.
铁死亡是一种铁依赖性的细胞死亡调节形式，其特征是细胞内活性氧物种的积累和脂质过氧化。它不仅在促进肿瘤的耐药性方面起着关键作用，而且在塑造各种恶性肿瘤的治疗方法方面也起着关键作用。本综述旨在通过讨论其概念框架、作用机制、功能方面以及对肿瘤治疗的意义，阐明铁死亡与头颈部癌症治疗之间的关系。此外，本综述还整合了通过调节铁死亡来提高头颈部癌症治疗效果的策略，为推进这一患者群体的治疗水平提供了有价值的参考。
