Single-Nucleotide Polymorphism in Genes Encoding G Protein Subunits and Increase the Risk of Cardiovascular Morbidity among Patients Undergoing Renal Replacement Therapy.

Single-nucleotide polymorphisms in G protein subunits are linked to an increased risk of cardiovascular events among the general population. We assessed the effects of c.825C > T, -695/-694GC > TT, and c.393C > T polymorphisms on the risk of cardiovascular events among 454 patients undergoing renal replacement therapy. The patients were followed up for a median of 4.5 years after the initiation of dialysis. Carriers of the TT/TT genotype of required stenting because of coronary artery stenosis ( = 0.0009) and developed cardiovascular events involving more than one organ system ( = 0.03) significantly earlier and more frequently than did the GC/TT or GC/GC genotypes. Multivariate analysis found that the TT/TT genotype of was an independent risk factor for coronary artery stenosis requiring stent (hazard ratio, 4.5; = 0.001), cardiovascular events (hazard ratio, 1.93; = 0.04) and cardiovascular events affecting multiple organs (hazard ratio, 4.9; = 0.03). In the subgroup of male patients left ventricular dilatation with abnormally increased LVEDD values occurred significantly more frequently in TT genotypes of than in CT/CC genotypes ( = 0.007). Our findings suggest that male dialysis patients carrying the TT genotype of are at higher risk of left ventricular dilatation and that dialysis patients carrying the TT/TT genotype of are prone to coronary artery stenosis and severe cardiovascular events.