Cipu Ruxandra-Ioana, Stănişteanu Mihai-Laurențiu, Andrei Mihaela-Aurelia, Banciu Daniel Dumitru, Banciu Adela
Department of Biomaterials and Medical Devices, Faculty of Medical Engineering, National University of Science and Technology Politehnica Bucharest, 1-7 Gh. Polizu Street, 011061 Bucharest, Romania.
J Funct Biomater. 2024 Oct 5;15(10):298. doi: 10.3390/jfb15100298.
Resistance to chemotherapy is a problem of major social and economic importance, when looking at factors like the decrease in life expectancy, the associated therapeutic costs, and a significant number of cancers that resist current chemotherapy. The development of chemotherapeutics for all theoretically possible tumor variants is an approach that requires unreasonable resources. We propose a theoretical model that serves the purpose of overcoming resistance to chemotherapeutic agents used in cancer therapy. The model describes a gene delivery system based on liposomes, which are optically guided to the tumor's location. The main aim of the gene delivery system is inhibiting the activity of enzymes involved in drug metabolism, hence offering the opportunity to use inexpensive chemotherapeutics that are already on the market. This model will reduce the costs of chemotherapy and will assure a positive outcome for patients.
当考虑到诸如预期寿命缩短、相关治疗成本以及大量对当前化疗产生耐药性的癌症等因素时，化疗耐药性是一个具有重大社会和经济意义的问题。针对所有理论上可能的肿瘤变体开发化疗药物是一种需要不合理资源的方法。我们提出了一个理论模型，其目的是克服癌症治疗中使用的化疗药物的耐药性。该模型描述了一种基于脂质体的基因递送系统，脂质体通过光学引导到达肿瘤位置。基因递送系统的主要目的是抑制参与药物代谢的酶的活性，从而提供使用市场上已有的廉价化疗药物的机会。该模型将降低化疗成本，并确保患者获得积极的治疗结果。
