Ettinger B, Genant H K, Cann C E
Ann Intern Med. 1987 Jan;106(1):40-5. doi: 10.7326/0003-4819-106-1-40.
Bone mass was measured prospectively in 73 women during the period immediately after menopause. By comparing the rates of loss at three skeletal sites, we assessed the protective effects of calcium supplements given alone or combined with low-dosage estrogen therapy. After 2 years of follow-up, spinal trabecular mineral content, measured by quantitative computed tomography, decreased by a mean of 9.0% (p = 0.002 compared with baseline) in untreated women and a mean of 10.5% (p = 0.0001) in women given calcium supplements alone. By contrast, women given conjugated estrogens, 0.3 mg/d, with calcium supplements showed an insignificant increase of 2.3%. Significant losses of a lesser magnitude were seen in the appendicular cortical skeleton of women not receiving therapy and in those receiving calcium alone, but no significant changes were observed in women receiving estrogen with calcium.
对73名绝经后不久的女性进行了前瞻性骨量测量。通过比较三个骨骼部位的骨质流失率，我们评估了单独补充钙或联合低剂量雌激素治疗的保护作用。经过2年的随访，通过定量计算机断层扫描测量，未接受治疗的女性脊柱小梁矿物质含量平均下降了9.0%（与基线相比，p = 0.002），单独补充钙的女性平均下降了10.5%（p = 0.0001）。相比之下，每天服用0.3毫克结合雌激素并补充钙的女性骨量仅微不足道地增加了2.3%。未接受治疗的女性以及仅接受钙治疗的女性的附属皮质骨骼出现了程度较小的显著骨质流失，但接受雌激素加钙治疗的女性未观察到显著变化。
