College of Materials and Environmental Engineering, Hangzhou Dianzi University, Hangzhou 310018, China.
Qianwan Institute, Ningbo Institute of Materials Technology and Engineering (NIMTE), Chinese Academy of Sciences, Ningbo 315201, China.
Sensors (Basel). 2023 Oct 23;23(20):8656. doi: 10.3390/s23208656.
Bisphenol A (BPA) is an industrial chemical used extensively in plastics and resins. However, its endocrine-disrupting properties pose risks to human health and the environment. Thus, accurate and rapid detection of BPA is crucial for exposure monitoring and risk mitigation. Molecularly imprinted electrochemical sensors (MIES) have emerged as a promising tool for BPA detection due to their high selectivity, sensitivity, affordability, and portability. This review provides a comprehensive overview of recent advances in MIES for BPA detection. We discuss the operating principles, fabrication strategies, materials, and methods used in MIES. Key findings show that MIES demonstrate detection limits comparable or superior to conventional methods like HPLC and GC-MS. Selectivity studies reveal excellent discrimination between BPA and structural analogs. Recent innovations in nanomaterials, novel monomers, and fabrication techniques have enhanced sensitivity, selectivity, and stability. However, limitations exist in reproducibility, selectivity, and stability. While challenges remain, MIES provide a low-cost portable detection method suitable for on-site BPA monitoring in diverse sectors. Further optimization of sensor fabrication and characterization will enable the immense potential of MIES for field-based BPA detection.
双酚 A（BPA）是一种广泛用于塑料和树脂的工业化学物质。然而，其内分泌干扰特性对人类健康和环境构成了风险。因此，准确快速地检测 BPA 对于暴露监测和风险缓解至关重要。分子印迹电化学传感器（MIES）由于其高选择性、灵敏度、可负担性和便携性，已成为 BPA 检测的一种有前途的工具。本综述全面概述了用于 BPA 检测的 MIES 的最新进展。我们讨论了 MIES 的工作原理、制造策略、材料和方法。主要发现表明，MIES 的检测限可与 HPLC 和 GC-MS 等传统方法相媲美或更优。选择性研究表明，MIES 可以极好地区分 BPA 和结构类似物。纳米材料、新型单体和制造技术的最新创新提高了传感器的灵敏度、选择性和稳定性。然而，在重现性、选择性和稳定性方面仍存在一些限制。尽管存在挑战，但 MIES 提供了一种低成本的便携式检测方法，适用于不同领域的现场 BPA 监测。进一步优化传感器的制造和表征将使 MIES 在现场 BPA 检测方面具有巨大的潜力。
