School of Food Science and Engineering, Key Laboratory of Tropical and Vegetables Quality and Safety for State Market Regulation, Hainan University, Haikou, 570228, China.
Leibniz-Institute of Photonic Technology, Member of the Leibniz Research Alliance, Leibniz Health Technologies, Albert-Einstein-Str. 9, 07745, Jena, Germany.
Anal Chim Acta. 2022 Oct 16;1230:340273. doi: 10.1016/j.aca.2022.340273. Epub 2022 Aug 19.
Electrochemical techniques have been demonstrated as powerful tools for various applications in analytical science. However, due to limited electrochemically active surface areas and poor anti-inference performance, their sensitivity and stability are weakened in real samples. By integrating electrochemical techniques with ratio-signal output modes and molecular imprinting polymers (MIPs), the newly constructed ratiometric molecularly imprinted electrochemical sensors (RMIECs) can outcompete conventional electrochemical techniques with higher sensitivity and stability, easier pretreatment, better selectivity and reproducibility, and are more adapted to complex environments. Fascinated by the superior performances of RMIECs, researchers from all research fields have been devoted to the design and development of RMIECs in different applications. For the first time, we summarize distinct ratiometric signal output modes and highlight four different types of RMIECs as well as their design, working principle and applications in analytical fields. In addition, the current challenges and prospects are carefully discussed to provide innovative idea tactics for developing new electrochemical methods.
电化学技术已被证明是分析科学中各种应用的有力工具。然而，由于电化学活性表面积有限和抗干扰性能差，它们在实际样品中的灵敏度和稳定性受到削弱。通过将电化学技术与比率信号输出模式和分子印迹聚合物（MIPs）相结合，新构建的比率分子印迹电化学传感器（RMIECs）可以比传统的电化学技术具有更高的灵敏度和稳定性、更简单的预处理、更好的选择性和重现性，并且更适应复杂环境。由于 RMIECs 的优越性能，来自各个研究领域的研究人员都致力于在不同的应用中设计和开发 RMIECs。我们首次总结了不同的比率信号输出模式，并重点介绍了四种不同类型的 RMIECs 及其在分析领域中的设计、工作原理和应用。此外，还仔细讨论了当前的挑战和展望，为开发新的电化学方法提供了创新的思路策略。
