Department of Biotechnology, University of Rijeka, 51000 Rijeka, Croatia.
Viruses. 2023 Sep 27;15(10):2007. doi: 10.3390/v15102007.
The Adenosine Deaminases Acting on RNA (ADAR) catalyze the posttranscriptional deamination of adenosine residues to inosine in double-stranded RNAs (dsRNAs, A-to-I editing), preventing the overactivation of dsRNA sensor molecules and interferons. RNA editing is the cornerstone of innate immunity that distinguishes between self and non-self (virus), and it is essential for normal regulation of cellular homeostasis. Although much is already known about the role of ADAR proteins in RNA virus infection, the role of ADAR proteins in herpesvirus infection remains largely unexplored. In this review, we provide several lines of evidence from studies of different herpesviruses for another level of complexity in regulating the already intricate biphasic life cycle of herpesviruses.
腺苷脱氨酶作用于 RNA（ADAR）催化双链 RNA（dsRNA，A 到 I 编辑）中腺苷残基的转录后脱氨作用为肌苷，防止 dsRNA 传感器分子和干扰素的过度激活。RNA 编辑是区分自身和非自身（病毒）的先天免疫的基石，也是细胞内稳态正常调节所必需的。尽管已经了解 ADAR 蛋白在 RNA 病毒感染中的作用，但 ADAR 蛋白在疱疹病毒感染中的作用在很大程度上仍未得到探索。在这篇综述中，我们从不同疱疹病毒的研究中提供了几条证据，证明了调节疱疹病毒已经复杂的双相生命周期的另一个复杂层次。
