Biomedical Sciences & Molecular Biology, College of Public Health, Medical and Veterinary Sciences, James Cook University, Townsville, QLD 4811, Australia.
Sydney School of Veterinary Science, The University of Sydney, Camden, NSW 2570, Australia.
Viruses. 2023 Oct 17;15(10):2106. doi: 10.3390/v15102106.
Cutaneous plantar papillomas are a relatively common lesion of wild psittacine birds in Australia. Next-generation sequencing technology was used to investigate the potential aetiologic agent(s) for a plantar cutaneous papilloma in a wild rainbow lorikeet (). In the DNA from this lesion, two novel viral sequences were detected. The first was the partial sequence of a herpesvirus with the proposed name, psittacid alphaherpesvirus 6, from the genus of the family alphaherpesviruses. This represents the first mardivirus to be detected in a psittacine bird, the first mardivirus to be detected in a wild bird in Australia, and the second mardivirus to be found in a biopsy of an avian cutaneous papilloma. The second virus sequence was a complete sequence of a hepadnavirus, proposed as parrot hepatitis B genotype H (PHBV-H). PHBV-H is the first hepadnavirus to be detected in a wild psittacine bird in Australia. Whether other similar viruses are circulating in wild birds in Australia and whether either of these viruses play a role in the development of the plantar papilloma will require testing of biopsies from similar lesions and normal skin from other wild psittacine birds.
皮肤足底乳头瘤是澳大利亚野生鹦鹉科鸟类中一种相对常见的病变。下一代测序技术被用于研究野生彩虹吸蜜鹦鹉足底皮肤乳头瘤的潜在病因。在该病变的 DNA 中，检测到了两个新的病毒序列。第一个是疱疹病毒的部分序列，暂定名为“禽α疱疹病毒 6”，属于α疱疹病毒科。这是在鹦鹉科鸟类中检测到的第一个 mardivirus，是在澳大利亚野生鸟类中检测到的第一个 mardivirus，也是在鸟类皮肤乳头瘤的活检中发现的第二个 mardivirus。第二个病毒序列是完整的 hepadnavirus 序列，建议命名为“鹦鹉乙型肝炎病毒基因型 H（PHBV-H）”。PHBV-H 是在澳大利亚野生鹦鹉科鸟类中检测到的第一个 hepadnavirus。是否有其他类似的病毒在澳大利亚的野生鸟类中传播，以及这些病毒是否在足底乳头瘤的发展中发挥作用，需要对来自类似病变的活检和其他野生鹦鹉科鸟类的正常皮肤进行检测。
