新型抗真菌剂SF 86-327的生物测定
Bioassay for SF 86-327, a new antifungal agent.
作者信息
Kan V L, Henderson D K, Bennett J E
出版信息
Antimicrob Agents Chemother. 1986 Oct;30(4):628-9. doi: 10.1128/AAC.30.4.628.
Abstract
A bioassay with Trichophyton mentagrophytes is described for SF 86-327, an allylamine antifungal agent. SF 86-327 serum concentrations were measured by bioassay in 117 serum sampler from five patients receiving 500 mg/day. The peak, trough, and area under the concentration-time curve were determined after the first dose and at steady state. Drug accumulation occurred with prolonged therapy.
摘要
描述了一种针对烯丙胺类抗真菌剂SF 86-327的须癣毛癣菌生物测定法。通过生物测定法测量了5名每日接受500毫克剂量的患者的117份血清样本中的SF 86-327血清浓度。在首剂用药后和稳态时测定了峰浓度、谷浓度和浓度-时间曲线下面积。长期治疗会出现药物蓄积。
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本文引用的文献
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