四种抗真菌药物在实验性小鼠孢子丝菌病中的疗效
Efficacies of four antifungal agents in experimental murine sporotrichosis.
作者信息
Kan V L, Bennett J E
机构信息
Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892.
出版信息
Antimicrob Agents Chemother. 1988 Nov;32(11):1619-23. doi: 10.1128/AAC.32.11.1619.
Abstract
Four antifungal agents, amphotericin B, SDZ 89-485, itraconazole, and terbinafine, were tested for efficacy in a murine model of systemic sporotrichosis. Survival in the groups treated with amphotericin B, SDZ 89-485, and itraconazole was significantly better than that of control infected mice. However, these agents did not wholly protect the infected mice, as tail and paw lesions, whole-body radiographs, and positive cultures from survivors showed evidence of dissemination. Terbinafine-treated mice had the same or poorer survival as control infected mice, despite documented drug absorption.
摘要
在系统性孢子丝菌病的小鼠模型中，对四种抗真菌药物——两性霉素B、SDZ 89 - 485、伊曲康唑和特比萘芬的疗效进行了测试。接受两性霉素B、SDZ 89 - 485和伊曲康唑治疗的组中的小鼠存活率显著高于未感染的对照小鼠。然而，这些药物并未完全保护感染的小鼠，因为存活小鼠的尾巴和爪子病变、全身X光片以及阳性培养结果显示有播散迹象。尽管有文献记载特比萘芬可被吸收，但接受特比萘芬治疗的小鼠存活率与未感染的对照小鼠相同或更低。
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