酿酒酵母的自发和诱导rho突变体：线粒体遗传标记的丢失模式
Spontaneous and induced rho mutants of Saccharomyces cerevisiae: patterns of loss of mitochondrial genetic markers.
作者信息
Heude M, Fukuhara H, Moustacchi E
出版信息
J Bacteriol. 1979 Aug;139(2):460-7. doi: 10.1128/jb.139.2.460-467.1979.
Abstract
The deletion which leads to spontaneous rho mutants occurs preferentially at a unique region covering genes oxi3, pho1/OII, and mit175. The frequency of loss of genetic markers in this region was significantly higher than in other regions as determined with a 15- marker system. When various mutagenic treatments were applied, this specific pattern of deletion was also observed, but it was dramatically amplified. This suggests that the basic mechanism of rho production is the same in yeast mitochondrial genomes in both spontaneous and induced mutants.
摘要
导致自发rho突变体的缺失优先发生在一个覆盖oxi3、pho1/OII和mit175基因的独特区域。用一个15标记系统测定，该区域遗传标记的丢失频率显著高于其他区域。当应用各种诱变处理时，也观察到这种特定的缺失模式，但它被显著放大。这表明在酵母线粒体基因组中，自发突变体和诱导突变体产生rho的基本机制是相同的。
相似文献
1
Spontaneous and induced rho mutants of Saccharomyces cerevisiae: patterns of loss of mitochondrial genetic markers.酿酒酵母的自发和诱导rho突变体：线粒体遗传标记的丢失模式
J Bacteriol. 1979 Aug;139(2):460-7. doi: 10.1128/jb.139.2.460-467.1979.
2
Preferential deletion of a specific region of mitochondrial DNA in Saccharomyces cerevisiae by ethidium bromide and 3-carbethoxy-psoralen: directional retention of DNA sequence.溴化乙锭和3-乙氧羰基补骨脂素对酿酒酵母线粒体DNA特定区域的优先缺失：DNA序列的定向保留
Mol Gen Genet. 1978 Jun 14;162(2):191-201. doi: 10.1007/BF00267876.
3
A novel class of Saccharomyces cerevisiae mutants specifically UV-sensitive to "petite" induction.一类对“小菌落”诱导特别对紫外线敏感的新型酿酒酵母突变体。
Mol Gen Genet. 1976 Nov 17;148(3):251-61. doi: 10.1007/BF00332899.
4
Mutants in yeast affecting ethidium bromide induced rho- formation and their effects on transmission and recombination of mitochondrial genes.酵母中影响溴化乙锭诱导的ρ-形成的突变体及其对线粒体基因传递和重组的影响。
Mol Gen Genet. 1979 Mar 20;171(2):205-14. doi: 10.1007/BF00270006.
5
Deletion of mitochondrial genetic markers in yeast by ethidium and the photoaffinity probe, ethidium azide.利用溴化乙锭和光亲和探针叠氮溴化乙锭删除酵母中的线粒体遗传标记。
Jpn J Med Sci Biol. 1979 Aug;32(4):219-23. doi: 10.7883/yoken1952.32.219.
6
Mapping of mitochondrial genes in Saccharomyces cerevisiae. Populations and pedigree analysis of retention or loss of four genetic markers in Rho-cells.酿酒酵母中线粒体基因的定位。Rho⁻细胞中四个遗传标记保留或丢失的群体及家系分析。
Mol Gen Genet. 1976 Jul 23;146(2):117-32. doi: 10.1007/BF00268080.
7
The fate of mitochondrial loci in rho minus mutants induced by ultraviolet irradiation of Saccharomyces cerevisiae: effects of different post-irradiation treatments.紫外线照射酿酒酵母诱导的ρ负突变体中线粒体基因座的命运：不同辐照后处理的影响
Genetics. 1979 Sep;93(1):81-103. doi: 10.1093/genetics/93.1.81.
8
The role of the nuclear gene "mitochondrial mutability control" (MMC1) in the process of mutability of the mitochondrial genome by different mutagens in Saccharomyces cerevisiae.核基因“线粒体突变控制”（MMC1）在酿酒酵母中不同诱变剂诱导线粒体基因组突变过程中的作用。
Mol Gen Genet. 1983;190(3):504-10. doi: 10.1007/BF00331083.
9
Co-mutagenic effects of propidium on petite induction by ethidium in Saccharomyces cerevisiae.溴化丙锭对酿酒酵母中溴化乙锭诱导小菌落形成的共诱变作用。
Mutat Res. 1980 Jan;69(1):43-50. doi: 10.1016/0027-5107(80)90174-8.
10
Petite deletion map of the mitochondrial oxi3 region in Saccharomyces cerevisiae.酿酒酵母线粒体oxi3区域的微小缺失图谱。
Mol Gen Genet. 1979 Jan 2;167(3):301-8. doi: 10.1007/BF00267423.
引用本文的文献
1
Learning from Yeast about Mitochondrial Carriers.从酵母中了解线粒体载体。
Microorganisms. 2021 Sep 28;9(10):2044. doi: 10.3390/microorganisms9102044.
2
Apoptosis, Induced by Human α-Synuclein in Yeast, Can Occur Independent of Functional Mitochondria.人α-突触核蛋白在酵母中诱导的细胞凋亡可以不依赖于功能线粒体而发生。
Cells. 2020 Sep 29;9(10):2203. doi: 10.3390/cells9102203.
3
Ccm1p is a 15S rRNA primary transcript processing factor as elucidated by a novel in vivo system in Saccharomyces cerevisiae.Ccm1p 是一种 15S rRNA 初级转录本加工因子，这是通过酿酒酵母中的一种新型体内系统阐明的。
Curr Genet. 2020 Aug;66(4):775-789. doi: 10.1007/s00294-020-01064-0. Epub 2020 Mar 9.
4
Mitochondrial mutagenesis in Saccharomyces cerevisiae : V. Frequencies of different mit (-) mutants and loss of their mit (+) alleles in rho (-) clones.酵母线粒体突变：V. rho(-)克隆中不同的mit(-)突变体的频率及其 mit(+)等位基因的丢失。
Curr Genet. 1981 Apr;3(1):57-63. doi: 10.1007/BF00419581.
5
Influence of the nuclear gene tmp3 on the loss of mitochondrial genes in Saccharomyces cerevisiae.核基因tmp3对酿酒酵母线粒体基因丢失的影响。
Mol Cell Biol. 1982 Apr;2(4):457-66. doi: 10.1128/mcb.2.4.457-466.1982.
6
Overexpression of the yeast transcriptional activator ADR1 induces mutation of the mitochondrial genome.酵母转录激活因子ADR1的过表达会诱导线粒体基因组发生突变。
Curr Genet. 1989 May;15(5):311-7. doi: 10.1007/BF00419910.
7
The fate of mitochondrial loci in rho minus mutants induced by ultraviolet irradiation of Saccharomyces cerevisiae: effects of different post-irradiation treatments.紫外线照射酿酒酵母诱导的ρ负突变体中线粒体基因座的命运：不同辐照后处理的影响
Genetics. 1979 Sep;93(1):81-103. doi: 10.1093/genetics/93.1.81.
本文引用的文献
1
The biogenesis of mitochondria. V. Cytoplasmic inheritance of erythromycin resistance in Saccharomyces cerevisiae.线粒体的生物发生。V. 酿酒酵母中红霉素抗性的细胞质遗传。
Proc Natl Acad Sci U S A. 1968 Mar;59(3):903-10. doi: 10.1073/pnas.59.3.903.
2
Mitochondrial genetics. VI. The petite mutation in Saccharomyces cerevisiae: interrelations between the loss of the p+ factor and the loss of the drug resistance mitochondrial genetic markers.线粒体遗传学。VI. 酿酒酵母中的小菌落突变：p+因子缺失与抗药性质粒遗传标记缺失之间的相互关系。
Genetics. 1974 Feb;76(2):195-219. doi: 10.1093/genetics/76.2.195.
3
Mitochondrial nucleic acids in the petite colonie mutants: deletions and repetition of genes.小菌落突变体中的线粒体核酸：基因缺失与重复
Biochimie. 1973;55(6):779-92. doi: 10.1016/s0300-9084(73)80030-6.
4
Complementation in cytoplasmic petite mutants of yeast to form respiratory competent cells.酵母细胞质小菌落突变体中的互补作用以形成呼吸功能正常的细胞。
Proc Natl Acad Sci U S A. 1975 Jan;72(1):372-5. doi: 10.1073/pnas.72.1.372.
5
Modified recombination and transmission of mitochondrial genetic markers in rho minus mutants of Saccharomyces cerevisiae.酿酒酵母ρ负突变体中线粒体遗传标记的修饰重组与传递
Proc Natl Acad Sci U S A. 1976 Dec;73(12):4608-12. doi: 10.1073/pnas.73.12.4608.
6
Mitochondrial genetic damage induced in yeast by a photoactivated furocoumarin in combination with ethidium bromide or ultraviolet light.光活化呋喃香豆素与溴化乙锭或紫外线联合作用于酵母诱导的线粒体遗传损伤。
Mol Gen Genet. 1976 Jun 15;145(3):249-54. doi: 10.1007/BF00325820.
7
Intramitochondrial ATP and cell functions. I. Growing yeast cells depleted of intramitochondrial ATP are losing mitochondrial genes.线粒体内的ATP与细胞功能。I. 线粒体内ATP耗尽的生长中的酵母细胞正在丢失线粒体基因。
Mol Gen Genet. 1978 Oct 25;166(1):103-16. doi: 10.1007/BF00379735.
8
Abnormal mitochondrial genomes in yeast restored to respiratory competence.酵母中恢复呼吸能力的异常线粒体基因组。
Genetics. 1978 Nov;90(3):517-30. doi: 10.1093/genetics/90.3.517.
9
Restriction enzyme analysis of mitochondrial DNAs of petite mutants of yeast: classification of petites, and deletion mapping of mitochondrial genes.酵母小菌落突变体线粒体DNA的限制性内切酶分析：小菌落的分类及线粒体基因的缺失定位
Mol Gen Genet. 1978 Jul 25;163(3):257-75. doi: 10.1007/BF00271955.
10
Physical mapping of genes on yeast mitochondrial DNA: localization of antibiotic resistance loci, and rRNA and tRNA genes.酵母线粒体DNA上基因的物理图谱：抗生素抗性位点以及rRNA和tRNA基因的定位
Mol Gen Genet. 1978 Jul 25;163(3):241-55. doi: 10.1007/BF00271954.
Zotero 插件