Jiang Kai, Cao Xiangjing, Wu Haitao, Xu Yifeng, Liu Lulu, Qian Haisheng, Miao Zhaohua, Wang Hua, Ma Yan
School of Food and Biological Engineering, Hefei University of Technology, Hefei, 230009, China.
Department of Oncology, The First Affiliated Hospital of Anhui Medical University, Hefei, 230022, China.
Adv Healthc Mater. 2024 Feb;13(4):e2302576. doi: 10.1002/adhm.202302576. Epub 2023 Nov 15.
Intestinal commensal microbiota dysbiosis and immune dysfunction are significant exacerbating factors in inflammatory bowel disease (IBD). To address these problems, Pluronic F-127-coated tungsten diselenide (WSe @F127) nanozymes are developed by simple liquid-phase exfoliation. The abundant valence transitions of elemental selenium (Se /Se ) and tungsten (W /W ) enable the obtained WSe @F127 nanozymes to eliminate reactive oxygen/nitrogen species. In addition, the released tungsten ions are capable of inhibiting the proliferation of Escherichia coli. In a model of dextran sodium sulfate-induced colitis, WSe @F127 nanozymes modulate the gut microbiota by increasing the abundance of bacteria S24-7 and significantly reducing the abundance of Enterobacteriaceae. Moreover, WSe @F127 nanozymes inhibit T-cell differentiation and improve intestinal immune barrier function in a model of Crohn's disease. The WSe @F127 nanozymes effectively alleviate IBD by reducing oxidative stress damage, modulating intestinal microbial populations, and remodeling the immune barrier.
肠道共生微生物群失调和免疫功能障碍是炎症性肠病（IBD）的重要加重因素。为了解决这些问题，通过简单的液相剥离法制备了普朗尼克F-127包覆的二硒化钨（WSe₂@F127）纳米酶。元素硒（Se⁰/Se²⁻）和钨（W⁴⁺/W⁶⁺）丰富的价态转变使所制备的WSe₂@F127纳米酶能够清除活性氧/氮物种。此外，释放出的钨离子能够抑制大肠杆菌的增殖。在葡聚糖硫酸钠诱导的结肠炎模型中，WSe₂@F127纳米酶通过增加细菌S24-7的丰度并显著降低肠杆菌科的丰度来调节肠道微生物群。此外，在克罗恩病模型中，WSe₂@F127纳米酶抑制T细胞分化并改善肠道免疫屏障功能。WSe₂@F127纳米酶通过减轻氧化应激损伤、调节肠道微生物群和重塑免疫屏障来有效缓解IBD。
