Chen Qi, Chen Qianyu, Su Guanyong, Chen Da, Ding Zhen, Sun Hong
Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, China; School of Public Health, Nanjing Medical University, Nanjing, China.
Jiangsu Key Laboratory of Chemical Pollution Control and Resources Reuse, School of Environmental and Biological Engineering, Nanjing University of Science and Technology, Nanjing, China.
Chemosphere. 2024 Jan;346:140545. doi: 10.1016/j.chemosphere.2023.140545. Epub 2023 Oct 27.
Little is known about the potential health impacts of benzophenone-type UV filters (BPs) exposure among the general population. In our study conducted in Wuxi, China, we investigated the associations between the concentrations of eight BP-derivatives and five target lipid molecules. We collected basic information, serum, and urine samples from 120 residents aged 9 to 80 in Wuxi. We determined BPs in urine samples and lipid levels in serum samples. Generalized linear models were used to evaluate the differences in ln-transformed serum target lipids levels (μg/L) with different urine BPs quartiles compared to the lowest quartile. Benzophenone-4 (BP-4) had the highest detection rate (95.0%) and geometric mean concentration (1.96 μg/L) among all the BP-derivatives in our study population. The exposure levels of BPs were generally higher in females than in males. Participants in the 9-17 and 18-50 age groups exhibited greater levels of exposure to BPs than those in the 51-80 age group. We observed statistically significant changes in LysoPC (18:0), LysoPE (18:0), ΣLPL, and ΣTL concentrations between the highest and lowest quartiles of BP-4. Similar changes were found in LysoPE (18:0) concentration between the highest and lowest quartiles of ΣBP-3 and ΣBPs. High urine BP concentrations were associated with variations in our target serum lipids involved in neurological and metabolic disorders, and posed a potential health risk. Future studies are warranted to further validate and elucidate our findings.
对于普通人群中接触二苯甲酮类紫外线过滤剂（BPs）对健康的潜在影响，人们了解甚少。在我们于中国无锡开展的研究中，我们调查了八种BP衍生物浓度与五种目标脂质分子之间的关联。我们从无锡120名年龄在9至80岁的居民中收集了基本信息、血清和尿液样本。我们测定了尿液样本中的BPs以及血清样本中的脂质水平。使用广义线性模型评估与最低四分位数相比，不同尿液BP四分位数下ln转换后的血清目标脂质水平（μg/L）的差异。在我们的研究人群中，二苯甲酮-4（BP-4）在所有BP衍生物中的检出率最高（95.0%），几何平均浓度为1.96μg/L。女性的BPs暴露水平总体上高于男性。9至17岁和18至50岁年龄组的参与者比51至80岁年龄组的参与者暴露于BPs的水平更高。我们观察到BP-4最高和最低四分位数之间，溶血磷脂酰胆碱（18:0）、溶血磷脂酰乙醇胺（18:0）、总脂蛋白（LPL）和总甘油三酯（TL）浓度有统计学上的显著变化。在总BP-3和总BPs的最高和最低四分位数之间，溶血磷脂酰乙醇胺（18:0）浓度也发现了类似变化。高尿液BP浓度与我们参与神经和代谢紊乱的目标血清脂质变化有关，并构成潜在健康风险。未来的研究有必要进一步验证和阐明我们的发现。
