预防性人乳头瘤病毒（HPV）疫苗能否降低手术后宫颈病变的复发率？综述与展望。
Can prophylactic HPV vaccination reduce the recurrence of cervical lesions after surgery? Review and prospect.
作者信息
Han Ling, Zhang Bingyi
机构信息
Department of Obstetrics and Gynecology, The First College of Clinical Medical Science, China Three Gorges University, Yichang City, Hubei Province, People's Republic of China.
Department of Obstetrics and Gynecology, Yichang Central People's Hospital, Yichang City, Hubei Province, People's Republic of China.
出版信息
Infect Agent Cancer. 2023 Oct 29;18(1):66. doi: 10.1186/s13027-023-00547-2.
Abstract
Women with HSIL typically undergo conization/LEEP to remove cervical lesions, but the risk of HSIL lesions returning after surgical treatment remains higher than in the general population. HPV vaccination is essential to prevent cervical cancer. However, the effect of prophylactic HPV vaccination on reducing the risk of recurrent cervical lesions after surgical treatment remains unclear. This review aims to analyze and summarize the latest literature on the role of prophylactic HPV vaccine in reducing the recurrence of cervical lesions after surgery in patients with HSIL, and to review and update the history, efficacy, effectiveness and safety of HPV vaccine, focusing on the current status of global HPV vaccine implementation and obstacles.
摘要
高级别鳞状上皮内病变（HSIL）的女性通常会接受锥切术/环形电切术（LEEP）以切除宫颈病变，但手术治疗后HSIL病变复发的风险仍高于普通人群。人乳头瘤病毒（HPV）疫苗接种对于预防宫颈癌至关重要。然而，预防性HPV疫苗接种对降低手术治疗后宫颈病变复发风险的效果仍不明确。本综述旨在分析和总结关于预防性HPV疫苗在降低HSIL患者手术后宫颈病变复发中作用的最新文献，并回顾和更新HPV疫苗的历史、疗效、有效性和安全性，重点关注全球HPV疫苗实施现状及障碍。
相似文献
1
Can prophylactic HPV vaccination reduce the recurrence of cervical lesions after surgery? Review and prospect.预防性人乳头瘤病毒（HPV）疫苗能否降低手术后宫颈病变的复发率？综述与展望。
Infect Agent Cancer. 2023 Oct 29;18(1):66. doi: 10.1186/s13027-023-00547-2.
2
Adjuvant VACcination against HPV in surgical treatment of Cervical Intra-epithelial Neoplasia (VACCIN study) a study protocol for a randomised controlled trial.辅助 HPV 疫苗接种治疗宫颈上皮内瘤变的手术治疗（VACCIN 研究）：一项随机对照试验的研究方案。
BMC Cancer. 2020 Jun 9;20(1):539. doi: 10.1186/s12885-020-07025-7.
3
Can Adjuvant HPV Vaccination Be Helpful in the Prevention of Persistent/Recurrent Cervical Dysplasia after Surgical Treatment?-A Literature Review.辅助性人乳头瘤病毒疫苗接种对手术治疗后持续性/复发性宫颈发育异常的预防是否有帮助？-文献综述
Cancers (Basel). 2022 Sep 7;14(18):4352. doi: 10.3390/cancers14184352.
4
The efficacy of human papillomavirus prophylactic vaccination after conization in preventing cervical intraepithelial neoplasia recurrence: A prospective observational study in China.宫颈锥切术后人乳头瘤病毒预防性疫苗接种对预防宫颈上皮内瘤变复发的疗效：中国的前瞻性观察研究。
Eur J Obstet Gynecol Reprod Biol. 2023 Jul;286:10-15. doi: 10.1016/j.ejogrb.2023.04.014. Epub 2023 Apr 19.
5
Effectiveness of Prophylactic Human Papillomavirus Vaccine in the Prevention of Recurrence in Women Conized for HSIL/CIN 2-3: The VENUS Study.预防性人乳头瘤病毒疫苗在预防因高级别鳞状上皮内病变/宫颈上皮内瘤变2-3级接受锥切术的女性复发中的有效性：金星研究
Vaccines (Basel). 2022 Feb 14;10(2):288. doi: 10.3390/vaccines10020288.
6
Human Papillomavirus Vaccination Prior to Loop Electroexcision Procedure Does Not Prevent Recurrent Cervical High-grade Squamous Intraepithelial Lesions in Women Living With Human Immunodeficiency Virus: A Randomized, Double-blind, Placebo-controlled Trial.人乳头瘤病毒疫苗接种在前环电切术之前并不能预防人类免疫缺陷病毒感染者中复发性宫颈高级别鳞状上皮内病变：一项随机、双盲、安慰剂对照试验。
Clin Infect Dis. 2021 Oct 5;73(7):e2211-e2216. doi: 10.1093/cid/ciaa1456.
7
[Analysis of recurrence and its influencing factors in patients with cervical HSIL within 24 months after LEEP].[leep术后24个月内宫颈HSIL患者复发情况及其影响因素分析]
Zhonghua Fu Chan Ke Za Zhi. 2019 Aug 25;54(8):534-540. doi: 10.3760/cma.j.issn.0529-567x.2019.08.006.
8
If prophylactic HPV vaccination is considered in a woman with CIN2+, what is the value and should it be given before or after the surgical treatment?如果考虑对 CIN2+的女性进行预防性 HPV 疫苗接种，其价值是什么，应该在手术治疗之前还是之后给予？
Eur J Obstet Gynecol Reprod Biol. 2022 Feb;269:98-101. doi: 10.1016/j.ejogrb.2021.11.008. Epub 2021 Nov 11.
9
Evaluation of the efficacy and safety of 5-aminolevulinic acid-mediated photodynamic therapy in women with high-risk HPV persistent infection after cervical conization.宫颈锥切术后高危型人乳头瘤病毒持续感染女性中5-氨基酮戊酸介导的光动力疗法的疗效和安全性评估
Photodiagnosis Photodyn Ther. 2022 Dec;40:103144. doi: 10.1016/j.pdpdt.2022.103144. Epub 2022 Oct 6.
10
Prophylactic HPV vaccination after conization: A systematic review and meta-analysis.宫颈锥切术后预防性 HPV 疫苗接种：系统评价和荟萃分析。
Vaccine. 2020 Sep 22;38(41):6402-6409. doi: 10.1016/j.vaccine.2020.07.055. Epub 2020 Aug 4.
引用本文的文献
1
The Role of Viruses in Cellular Transformation and Cancer.病毒在细胞转化和癌症中的作用。
Cancer Rep (Hoboken). 2025 Feb;8(2):e70150. doi: 10.1002/cnr2.70150.
2
Exploring the Intricacies of Cervical Intraepithelial Neoplasia and Its Connection with HPV: A Narrative Review.探索宫颈上皮内瘤变的复杂性及其与HPV的关联：一篇叙述性综述
Iran J Public Health. 2024 Dec;53(12):2671-2682.
3
Drugs and drug targets for the treatment of HPV-positive cervical cancer.用于治疗人乳头瘤病毒（HPV）阳性宫颈癌的药物和药物靶点。
Tumour Virus Res. 2024 Dec 19;19:200309. doi: 10.1016/j.tvr.2024.200309.
4
Risks of Cervical Cancer Recurrence After Fertility-Sparing Surgery and the Role of Human Papillomavirus Infection Types.保留生育功能手术后宫颈癌复发的风险及人乳头瘤病毒感染类型的作用
J Clin Med. 2024 Oct 22;13(21):6318. doi: 10.3390/jcm13216318.
5
Nationwide Discrete Choice Experiment on Chinese Guardians' Preferences for HPV Vaccination for Mothers and Daughters.关于中国监护人对母亲和女儿HPV疫苗接种偏好的全国性离散选择实验。
Vaccines (Basel). 2024 Oct 18;12(10):1186. doi: 10.3390/vaccines12101186.
6
HPV Infections-Classification, Pathogenesis, and Potential New Therapies.HPV 感染——分类、发病机制与潜在新疗法。
Int J Mol Sci. 2024 Jul 11;25(14):7616. doi: 10.3390/ijms25147616.
7
Controversies and Advances in the Personalized Surgical Treatment of Cervical Cancer.宫颈癌个体化手术治疗的争议与进展
J Pers Med. 2024 Jun 6;14(6):606. doi: 10.3390/jpm14060606.
8
Why so much uncertainty about adjuvant HPV vaccines after local treatment? Can the discrepancy between the positive statistical results and the scientific community doubts be solved?为什么局部治疗后辅助性人乳头瘤病毒（HPV）疫苗存在如此多的不确定性？阳性统计结果与科学界的质疑之间的差异能否得到解决？
Infect Agent Cancer. 2024 Apr 4;19(1):11. doi: 10.1186/s13027-024-00572-9.
本文引用的文献
1
Myths and fake messages about human papillomavirus (HPV) vaccination: answers from the ESGO Prevention Committee.关于人乳头瘤病毒（HPV）疫苗接种的谣言与虚假信息：欧洲妇科肿瘤学会预防委员会的解答
Int J Gynecol Cancer. 2022 Oct 3;32(10):1316-1320. doi: 10.1136/ijgc-2022-003685.
2
HPV Vaccination in Women with Cervical Intraepithelial Neoplasia Undergoing Excisional Treatment: Insights into Unsolved Questions.接受切除治疗的宫颈上皮内瘤变女性的HPV疫苗接种：对未解决问题的见解
Vaccines (Basel). 2022 Jun 1;10(6):887. doi: 10.3390/vaccines10060887.
3
Effectiveness of Prophylactic Human Papillomavirus Vaccine in the Prevention of Recurrence in Women Conized for HSIL/CIN 2-3: The VENUS Study.预防性人乳头瘤病毒疫苗在预防因高级别鳞状上皮内病变/宫颈上皮内瘤变2-3级接受锥切术的女性复发中的有效性：金星研究
Vaccines (Basel). 2022 Feb 14;10(2):288. doi: 10.3390/vaccines10020288.
4
If prophylactic HPV vaccination is considered in a woman with CIN2+, what is the value and should it be given before or after the surgical treatment?如果考虑对 CIN2+的女性进行预防性 HPV 疫苗接种，其价值是什么，应该在手术治疗之前还是之后给予？
Eur J Obstet Gynecol Reprod Biol. 2022 Feb;269:98-101. doi: 10.1016/j.ejogrb.2021.11.008. Epub 2021 Nov 11.
5
Rationale and design of a double-blind randomized non-inferiority clinical trial to evaluate one or two doses of vaccine against human papillomavirus including an epidemiologic survey to estimate vaccine efficacy: The Costa Rica ESCUDDO trial.评估含人乳头瘤病毒疫苗一剂或两剂的双盲随机非劣效性临床试验的原理和设计：哥斯达黎加 ESCUDDO 试验。
**注**：该临床试验旨在评估含人乳头瘤病毒疫苗一剂或两剂的免疫效果，通过双盲随机非劣效性设计，以评估疫苗的有效性。
Vaccine. 2022 Jan 3;40(1):76-88. doi: 10.1016/j.vaccine.2021.11.041. Epub 2021 Nov 29.
6
Worldwide trends in cervical cancer incidence and mortality, with predictions for the next 15 years.全球宫颈癌发病率和死亡率趋势，以及未来 15 年的预测。
Cancer. 2021 Nov 1;127(21):4030-4039. doi: 10.1002/cncr.33795. Epub 2021 Aug 9.
7
Human Papilloma Virus Vaccination.人乳头瘤病毒疫苗接种。
Viruses. 2021 Jun 8;13(6):1091. doi: 10.3390/v13061091.
8
Human papillomavirus persistence or clearance after infection in reproductive age. What is the status? Review of the literature and new data of a vaginal gel containing silicate dioxide, citric acid, and selenite.人乳头瘤病毒在生殖年龄后的持续感染或清除。现状如何？文献复习和一种含硅酸钠、柠檬酸和亚硒酸盐的阴道凝胶的新数据。
Womens Health (Lond). 2021 Jan-Dec;17:17455065211020702. doi: 10.1177/17455065211020702.
9
Adjuvant HPV Vaccination to Prevent Recurrent Cervical Dysplasia after Surgical Treatment: A Meta-Analysis.辅助性人乳头瘤病毒疫苗预防手术治疗后复发性宫颈发育异常：一项荟萃分析。
Vaccines (Basel). 2021 Apr 21;9(5):410. doi: 10.3390/vaccines9050410.
10
Human Papillomavirus Vaccination After COVID-19.新冠病毒感染后的人乳头瘤病毒疫苗接种
JNCI Cancer Spectr. 2021 Mar 2;5(2):pkab011. doi: 10.1093/jncics/pkab011. eCollection 2021 Apr.
Zotero 插件