Schlesinger D, Hałasa J, Mańczak M
Arch Immunol Ther Exp (Warsz). 1986;34(2):149-55.
Examination of GPT system in 5418 paternity cases confirmed the elimination of maternity in 21 cases. The study of 12 probant families displayed the occurrence of opposite homozygous types in parents and children. The result obtained showed the presence of GPT0 gene in the families examined. Similar results were obtained by examining five families of alleged fathers whose paternity was eliminated on the same basis. In 12 families the activity of GPT was determined. In majority of subjects with GPT0 gene, markedly lowered activity was observed. This also concerned several homozygous subjects who were identical with their parents. The lowered activity of the enzyme is not present in all subjects with a "silent gene", and therefore, its examination cannot be used for detection of the gene.
对5418例亲子鉴定案例中的GPT系统进行检测，证实有21例排除了母系关系。对12个先证者家庭的研究显示，父母与子女中出现了相反的纯合子类型。所获结果表明，在所检测的家庭中存在GPT0基因。通过检测另外五个基于相同理由排除父系关系的所谓父亲的家庭，也得到了类似结果。对12个家庭的GPT活性进行了测定。在大多数具有GPT0基因的受试者中，观察到活性明显降低。这也涉及一些与其父母相同的纯合子受试者。并非所有具有“沉默基因”的受试者都存在酶活性降低的情况，因此，对其检测不能用于该基因的检测。
