Chavada Jay, Muneshwar Komal N, Ghulaxe Yash, Wani Mohit, Sarda Prayas P, Huse Shreyash
Department of Community Medicine, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education and Research, Wardha, IND.
Cureus. 2023 Sep 26;15(9):e46013. doi: 10.7759/cureus.46013. eCollection 2023 Sep.
From a broader perspective, antibiotic or antimicrobial resistance is still evolving and spreading internationally. Infectious diseases have become more complex and often impossible to cure, increasing morbidity and mortality. Despite the failure of conventional, standard antimicrobial therapy, no new class of antibiotics has been developed in the last 20 years, which results in various cutting-edge and other tactics that can be used to encounter these disease-causing microorganisms with antibiotic resistance. In the continued fight against bacterial infections, there is an urgent requirement for new antibiotics and other antimicrobials. Antibiotic resistance is inevitable, and pharmaceutical companies consistently show little interest in funding novel antibiotic research. Some methods are being used as a possible replacement for conventional antibiotics. Combination therapy, methods that target the proteins or enzymes that cause antimicrobial resistance and bacterial resistance, systems for delivery of the drug, physicochemical approaches, and informal ways, such as the CRISPR-Cas system, are some of these approaches. These various approaches influence how multi-drug-resistant organisms are handled in human clinical settings.
从更广泛的角度来看，抗生素或抗菌药物耐药性仍在国际上不断演变和传播。传染病变得更加复杂，往往无法治愈，导致发病率和死亡率上升。尽管传统的标准抗菌疗法失败了，但在过去20年里没有开发出新型抗生素，这导致了各种前沿及其他策略，可用于对抗这些具有抗生素耐药性的致病微生物。在持续对抗细菌感染的过程中，迫切需要新型抗生素和其他抗菌药物。抗生素耐药性不可避免，制药公司一直对资助新型抗生素研究兴趣寥寥。一些方法正被用作传统抗生素的可能替代品。联合疗法、针对导致抗菌药物耐药性和细菌耐药性的蛋白质或酶的方法、药物递送系统、物理化学方法以及诸如CRISPR-Cas系统等非正规方法，都是其中的一些方法。这些不同的方法影响着人类临床环境中对多重耐药生物体的处理方式。
