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妊娠晚期新诊断的溃疡性结肠炎:病例报告

Newly Diagnosed Ulcerative Colitis in the Third Trimester: A Case Report.

作者信息

Rodriguez Arley K, Muir Sean M, Tjiattas-Saleski Lindsay

机构信息

Obstetrics and Gynecology, Edward Via College of Osteopathic Medicine, Spartanburg, USA.

Medicine, Edward Via College of Osteopathic Medicine, Spartanburg, USA.

出版信息

Cureus. 2023 Sep 26;15(9):e46004. doi: 10.7759/cureus.46004. eCollection 2023 Sep.

DOI:10.7759/cureus.46004
PMID:37900441
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10602013/
Abstract

Ulcerative colitis is a chronic inflammatory bowel disease that results in continuous colon inflammation. It is uncommonly diagnosed during pregnancy, and if quiescent before pregnancy, becomes active very rarely. Current literature has found that amelioration of the disease can be common during the second and third trimesters. However, if ulcerative colitis is active, it has the potential to result in premature delivery and low birth weight. This case focuses on a rare presentation of primary ulcerative colitis diagnosed in a 22-year-old multiparous patient to highlight the importance of a comprehensive differential diagnosis in pregnant patients with seemingly benign symptomatology.

摘要

溃疡性结肠炎是一种慢性炎症性肠病,可导致结肠持续炎症。妊娠期很少诊断出该病,若在妊娠前病情静止,则极少会复发。目前的文献发现,该病在妊娠中期和晚期病情缓解较为常见。然而,如果溃疡性结肠炎处于活动期,则有可能导致早产和低出生体重。本病例聚焦于一名22岁经产妇被诊断为原发性溃疡性结肠炎的罕见病例,以强调对症状看似良性的妊娠患者进行全面鉴别诊断的重要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16f5/10602013/e3264f77a1c3/cureus-0015-00000046004-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16f5/10602013/e3264f77a1c3/cureus-0015-00000046004-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/16f5/10602013/e3264f77a1c3/cureus-0015-00000046004-i01.jpg

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1
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本文引用的文献

1
The Maternal-Fetal Gut Microbiota Axis: Physiological Changes, Dietary Influence, and Modulation Possibilities.母婴肠道微生物群轴:生理变化、饮食影响及调节可能性
Life (Basel). 2022 Mar 15;12(3):424. doi: 10.3390/life12030424.
2
British Society of Gastroenterology consensus guidelines on the management of inflammatory bowel disease in adults.英国胃肠病学会成人炎症性肠病管理共识指南。
Gut. 2019 Dec;68(Suppl 3):s1-s106. doi: 10.1136/gutjnl-2019-318484. Epub 2019 Sep 27.
3
Modulation of cytokine patterns and microbiome during pregnancy in IBD.
炎症性肠病患者妊娠期间细胞因子谱和微生物组的调节。
Gut. 2020 Mar;69(3):473-486. doi: 10.1136/gutjnl-2019-318263. Epub 2019 Jun 5.
4
ACG Clinical Guideline: Ulcerative Colitis in Adults.ACG 临床指南:成人溃疡性结肠炎。
Am J Gastroenterol. 2019 Mar;114(3):384-413. doi: 10.14309/ajg.0000000000000152.
5
AGA Clinical Practice Guidelines on the Management of Mild-to-Moderate Ulcerative Colitis.美国胃肠病学会关于轻至中度溃疡性结肠炎管理的临床实践指南。
Gastroenterology. 2019 Feb;156(3):748-764. doi: 10.1053/j.gastro.2018.12.009. Epub 2018 Dec 18.
6
Salvage therapy for acute severe ulcerative colitis during pregnancy.妊娠期急性重症溃疡性结肠炎的挽救治疗
BMJ Case Rep. 2018 Jun 8;2018:bcr-2017-223540. doi: 10.1136/bcr-2017-223540.
7
Ulcerative colitis.溃疡性结肠炎。
Lancet. 2017 Apr 29;389(10080):1756-1770. doi: 10.1016/S0140-6736(16)32126-2. Epub 2016 Dec 1.
8
Fulminant ulcerative colitis in a healthy pregnant woman.一名健康孕妇患暴发性溃疡性结肠炎。
World J Gastroenterol. 2015 May 21;21(19):6060-4. doi: 10.3748/wjg.v21.i19.6060.
9
Can inflammatory bowel disease be permanently treated with short-term interventions on the microbiome?炎症性肠病能否通过对微生物群的短期干预得到根治?
Expert Rev Gastroenterol Hepatol. 2015 Jun;9(6):781-95. doi: 10.1586/17474124.2015.1013031. Epub 2015 Feb 10.
10
Inflammatory bowel disease and pregnancy.炎症性肠病与妊娠
Gastroenterol Clin North Am. 1998 Mar;27(1):213-24. doi: 10.1016/s0889-8553(05)70354-x.