聚乙二醇6000对精胺诱导的脂质体聚集的影响。
The influence of poly(ethylene glycol) 6000 on spermine-induced aggregation of liposomes.
作者信息
Tadolini B, Varani E, Cabrini L
出版信息
Biochem J. 1986 Jun 15;236(3):651-5. doi: 10.1042/bj2360651.
Abstract
Poly(ethylene glycol) 6000 affected the aggregation of mixed liposomes induced by spermine. It lowered the concentration of spermine causing 50% maximal aggregation, accelerated the rate and increased the extent of aggregation. The effect was inversely proportional to the density of the acidic phospholipid in the vesicles. These effects were not due either to poly(ethylene glycol) 6000-induced permanent structural modification of the liposome or increased binding of spermine to the vesicles. These findings are discussed in relation to a decreased hydration force caused by the ability of poly(ethylene glycol) 6000 to alter the water of hydration of the phospholipid polar groups in the liposome.
摘要
聚乙二醇6000影响了精胺诱导的混合脂质体的聚集。它降低了导致50%最大聚集的精胺浓度，加快了聚集速率并增加了聚集程度。该效应与囊泡中酸性磷脂的密度成反比。这些效应既不是由于聚乙二醇6000诱导脂质体的永久性结构改变，也不是由于精胺与囊泡的结合增加。结合聚乙二醇6000改变脂质体中磷脂极性基团水化水的能力所导致的水化力降低，对这些发现进行了讨论。
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