Departments of Chemistry and Biomedical Sciences, University of Hull, Cottingham Road, Hull, HU6 7RX, UK.
School of Chemistry, University of East Anglia, Norwich Research Park, Norwich, NR4 7TJ, UK.
Chem Commun (Camb). 2023 Nov 14;59(91):13623-13626. doi: 10.1039/d3cc03430e.
A novel diacetylpyridylcarbohydrazide-DAPyCOHz-based manganese(II) chelate with dipicolylamine/zinc(II) (DPA/Zn) arms (MnLDPA-Zn2) was developed for adenosine triphosphate (ATP) responsive magnetic resonance imaging (MRI) contrast applications. Compound 2 shows enhanced relaxivity ( = 11.52 mM s) upon selective ATP binding over other phosphates.
一种新型的基于二乙酰基吡啶基碳酰肼-DAPyCOHz 的锰(II)螯合物，带有二吡啶基胺/锌(II)（DPA/Zn）臂（MnLDPA-Zn2），用于三磷酸腺苷（ATP）响应磁共振成像（MRI）对比应用。化合物 2 在选择性结合 ATP 时表现出增强的弛豫率（r1 = 11.52 mM s），超过了其他磷酸盐。
