Kwon Hyo Eun, Ko Nayeon, Yuk Doyoung, Choi Seo Won, Koh Seong-Eun
Department of Rehabilitation Medicine, Konkuk University Medical Center, and Konkuk University School of Medicine, Konkuk University, Seoul, Korea.
Ann Rehabil Med. 2023 Oct;47(5):358-366. doi: 10.5535/arm.23076. Epub 2023 Oct 23.
: To systematically review the effects of protein supplementation in older adults with sarcopenia.
: A systematic literature search was conducted in PubMed, Cochrane Library, and Embase databases until May 2023. The inclusion criteria were as follows: (1) randomized controlled trials with a quantitative study design; (2) studies with a study group of older adults with sarcopenia; (3) studies comparing muscle mass, muscle strength, and performance of older adults with sarcopenia after protein supplementation; and (4) studies published up to May 2023.
: Six retrospective comparative studies, including 715 patients, met the inclusion criteria. The nutritional supplementation group exhibited significant improvement in appendicular skeletal muscle mass (standardized mean difference [SMD]=0.41; 95% confidence interval [CI], 0.24-0.58; p<0.001; I=1%), while handgrip strength (SMD=0.37; 95% CI, -0.32-1.07; p=0.29; I=94%) and Short Physical Performance Battery (SPPB) (SMD=0.35; 95% CI, -0.47-1.18; p=0.40; I=94%) showed a tendency for improvement.
: Nutritional supplementation with protein increased appendicular muscle mass in older adults with sarcopenia and improved handgrip strength and SPPB scores.
系统评价补充蛋白质对老年肌少症患者的影响。
截至2023年5月，在PubMed、Cochrane图书馆和Embase数据库中进行了系统的文献检索。纳入标准如下：（1）采用定量研究设计的随机对照试验；（2）研究对象为老年肌少症患者的研究；（3）比较补充蛋白质后老年肌少症患者肌肉质量、肌肉力量和运动能力的研究；（4）截至2023年5月发表的研究。
六项回顾性比较研究，共715例患者，符合纳入标准。营养补充组的四肢骨骼肌质量有显著改善（标准化均数差[SMD]=0.41；95%置信区间[CI]，0.24-0.58；p<0.001；I²=1%），而握力（SMD=0.37；95%CI，-0.32-1.07；p=0.29；I²=94%）和简短体能测试电池（SPPB）（SMD=0.35；95%CI，-0.47-1.18；p=0.40；I²=94%）有改善趋势。
补充蛋白质营养可增加老年肌少症患者的四肢肌肉质量，并改善握力和SPPB评分。
