Department of Anatomical Sciences, Faculty of Medicine, Arak University of Medical Sciences, Arak, Iran.
J Wound Care. 2023 Nov 1;32(Sup11):S24-S35. doi: 10.12968/jowc.2023.32.Sup11.S24.
Diabetes describes a group of metabolic disorders characterised by increased blood glucose concentration. People living with diabetes have a higher risk of morbidity and mortality than the general population. In 2015 it was estimated that there were 415 million (uncertainty interval: 340-536 million) people with diabetes aged 20-79 years, and 5.0 million deaths attributable to diabetes. When diabetic patients develop an ulcer, they become at high risk for major complications, including infection and amputation. The pathophysiologic relationship between diabetes and impaired healing is complex. Vascular, neuropathic, immune function, and biochemical abnormalities each contribute to the altered tissue repair. The use of herbal medicine has increased and attracted the attention of many researchers all over the world. In this study, we have evaluated the effect of 500mg/kg hydroalcoholic extract of leaves (TFG-E) on wound healing in diabetic rats using a full-thickness cutaneous incisional wound model. Wounds of treated animals showed better tensiometric indices, accelerated wound contraction, faster re-epithelialisation, improved neovascularisation, better modulation of fibroblasts and macrophage presence in the wound bed and moderate collagen formation.
糖尿病描述了一组以血糖浓度升高为特征的代谢紊乱。与一般人群相比，糖尿病患者的发病率和死亡率更高。2015 年估计，20-79 岁的糖尿病患者有 4.15 亿（不确定区间：3.40-5.36 亿），500 万例糖尿病死亡。当糖尿病患者出现溃疡时，他们会面临严重并发症的高风险，包括感染和截肢。糖尿病与愈合受损之间的病理生理关系很复杂。血管、神经病变、免疫功能和生化异常都导致组织修复的改变。草药的使用增加了，并引起了世界各地许多研究人员的关注。在这项研究中，我们使用全层皮肤切口伤口模型评估了 500mg/kg 叶水醇提取物（TFG-E）对糖尿病大鼠伤口愈合的影响。治疗动物的伤口表现出更好的张力计指数、加速伤口收缩、更快的再上皮化、改善新血管生成、更好地调节伤口床中的成纤维细胞和巨噬细胞存在以及适度的胶原蛋白形成。
