体重指数对体外受精中异位妊娠的影响：对 42362 个临床妊娠周期的分析。
Body mass index impacts ectopic pregnancy during in vitro fertilization: an analysis of 42,362 clinical pregnancy cycles.
机构信息
Reproductive Medical Center, the First Affiliated Hospital of Zhengzhou University, 1# Jianshe East Road, Zhengzhou, China.
Henan Institute of Medical and Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, 450052, China.
出版信息
Reprod Biol Endocrinol. 2023 Oct 31;21(1):105. doi: 10.1186/s12958-023-01146-x.
PURPOSE
This large, single-center, retrospective cohort study was aimed to explore the effect of female body mass index (BMI) on ectopic pregnancy (EP) following fresh and frozen-thawed embryo transfers (ET).
METHODS
A total of 27,600 pregnancies after fresh ET and 14,762 pregnancies after frozen-thawed ET were included between January 2010 to June 2022. Women were divided into three groups based on BMI according to the Working Group on Obesity in China (WGOC), International Life Sciences Institute (ILSI): underweight (BMI < 18.5 kg/m), normal weight (BMI, 18.5-23.9 kg/m), and overweight or obesity (≥ 24 kg/m). Compare EP rates among BMI categories in fresh and frozen-thawed ET cycles respectively. Multivariate logistic regression analyses were used to investigate the association between female BMI and EP.
RESULTS
The overall EP rates in fresh, and frozen thawed transfer cycles were 2.43% (672/27,600) and 2.82% (417/14,762), respectively. In fresh ET cycles, underweight women yielded a significantly higher EP rate than those with normal and excess weight (3.29% vs. 2.29% vs. 2.54%, P = 0.029). But EP rates did not differ among the three BMI groups (2.72% vs. 2.76% vs. 2.96%, P = 0.782) in frozen-thawed ET cycles. In fresh ET cycles, after adjusting for potential confounding factors, no significant association was found between female BMI and EP occurrence (adjusted OR: 0.98, 95% CI 0.70-1.37, P = 0.894, for BMI 18.5-23.9 kg/m; adjusted OR: 0.89, 95% CI 0.75-1.06, P = 0.205, for BMI ≥ 24 kg/m. Reference = BMI < 18.5 kg/m).
CONCLUSION(S): Female BMI did not affect the occurrence of ectopic pregnancy in either fresh or frozen-thawed embryo transfer cycles.
目的
本研究旨在探讨女性体重指数（BMI）对新鲜和冻融胚胎移植（ET）后异位妊娠（EP）的影响。
方法
纳入 2010 年 1 月至 2022 年 6 月期间新鲜 ET 后 27600 例妊娠和冻融 ET 后 14762 例妊娠。根据中国肥胖工作组（WGOC）和国际生命科学学会（ILSI）的标准，女性按照 BMI 分为三组：体重不足（BMI<18.5kg/m2）、正常体重（BMI，18.5-23.9kg/m2）和超重或肥胖（≥24kg/m2）。分别比较新鲜和冻融 ET 周期中 BMI 类别之间的 EP 发生率。采用多变量逻辑回归分析来探讨女性 BMI 与 EP 的关系。
结果
新鲜和冻融 ET 周期的总体 EP 发生率分别为 2.43%（672/27600）和 2.82%（417/14762）。在新鲜 ET 周期中，体重不足的女性 EP 发生率明显高于正常体重和超重肥胖的女性（3.29% vs. 2.29% vs. 2.54%，P=0.029）。然而，在冻融 ET 周期中，三个 BMI 组之间的 EP 发生率没有差异（2.72% vs. 2.76% vs. 2.96%，P=0.782）。在新鲜 ET 周期中，在调整潜在混杂因素后，女性 BMI 与 EP 发生之间没有显著关联（调整后的 OR：0.98，95%CI 0.70-1.37，P=0.894，对于 BMI 18.5-23.9kg/m2；调整后的 OR：0.89，95%CI 0.75-1.06，P=0.205，对于 BMI≥24kg/m2。参考=BMI<18.5kg/m2）。
结论
女性 BMI 不会影响新鲜或冻融胚胎移植周期中 EP 的发生。
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