Li Shu, Zhang Kelan, Yang Liu, Wu Jia, Bhargava Neha, Li Yinghua, Gao Fei
Department of Clinical Laboratory, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, No. 9 Jinsui Road, Tianhe District, Guangzhou, 510620, Guangdong, China.
Reproductive Medicine Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, No.1095 Jie Fang Avenue, Wuhan, 430030, Hubei Province, China.
Infect Agent Cancer. 2023 Oct 31;18(1):67. doi: 10.1186/s13027-023-00541-8.
Cervical cancer is associated with high-risk human papillomavirus (HR-HPV) infection in the world. We aimed to evaluate the status of HPV infection among women in Guangzhou, China.
The study recruited 28,643 female patients from the Guangzhou Women and Children's Medical Center for HPV genotype testing between 2019 and 2021.
5668 patients were infected with HPV, resulting in an overall infection prevalence of 19.78%. The prevalence of HR-HPV was recorded at 13.94% (both single-infections and multi-infections), probably high-risk HPV/possibly carcinogenic (pHR-HPV) as 3.51%; and low-risk HPV (LR-HPV) as 3.56%. The most common HR-HPV genotype detected was HPV-52 with an infection rate of 4.99%, followed by HPV 58 (2.18%), 16 (2.12%), 51 (1.61%), 39 (1.19%), 56 (1.09%), 59 (0.85%), 18 (0.72%), 33 (0.61%), 31 (0.53%), 35 (0.20%), 45 (0.17%). Among LR-HPV genotypes, HPV-42 was the most common (1.08%), followed by 44 (0.77%), 81 (0.68%), 6 (0.48%), 43 (0.40%), 11 (0.23%) and 83 (0.07%). The prevalence of infection among different genotypes in pHR-HPV was: 68 (1.29%), 53 (1.21%), 66 (0.77%), 82 (0.25%), 73 (0.16%). Additionally, the prevalence of single genotype HPV infection exceeded that of multiple HPV infections except HPV-59.
Our findings imply that HPV genotype infections in Guangzhou demonstrate a regional and age-related distribution. Therefore, these data can provide a substantial foundation for further epidemiologic analysis to control and prevent HPV infections in Guangzhou.
在全球范围内，宫颈癌与人乳头瘤病毒（HR-HPV）感染相关。我们旨在评估中国广州女性的HPV感染状况。
该研究在2019年至2021年期间招募了来自广州妇女儿童医疗中心的28643名女性患者进行HPV基因分型检测。
5668例患者感染了HPV，总体感染率为19.78%。HR-HPV的感染率为13.94%（包括单一感染和多重感染），可能致癌的高危HPV（pHR-HPV）为3.51%；低危HPV（LR-HPV）为3.56%。检测到的最常见HR-HPV基因型是HPV-52，感染率为4.99%，其次是HPV 58（2.18%）、16（2.12%）、51（1.61%）、39（1.19%）、56（1.09%）、59（0.85%）、18（0.72%）、33（0.61%）、31（0.53%）、35（0.20%）、45（0.17%）。在LR-HPV基因型中，HPV-42最常见（1.08%），其次是44（0.77%）、81（0.68%）、6（0.48%）、43（0.40%）、11（0.23%）和83（0.07%）。pHR-HPV中不同基因型的感染率为：68（1.29%）、53（1.21%）、66（0.77%）、82（0.25%）、73（0.16%）。此外，除HPV-59外，单一基因型HPV感染的发生率超过了多重HPV感染。
我们的研究结果表明，广州的HPV基因型感染呈现出地区和年龄相关的分布。因此，这些数据可为进一步的流行病学分析提供坚实基础，以控制和预防广州的HPV感染。
