Wei Liuting, Ma Liping, Qin Lingyan, Huang Zhihu
Department of Clinical Laboratory, Minzu Hospital of Guangxi Zhuang Autonomous Region, Affiliated Minzu Hospital of Guangxi Medical University, Nanning, 530001, Guangxi Zhuang Autonomous Region, China.
Infect Agent Cancer. 2022 Apr 21;17(1):19. doi: 10.1186/s13027-022-00431-5.
Human papillomavirus is a primary cause of cervical cancer and genital warts. HPV vaccine can prevent high-grade cervical lesions as well as cervical cancer. The aim of this study was to analyze the prevalence and genotype distribution of human papillomavirus among women in Guangxi before and after the HPV vaccine was approved for use in China.
From January 2016 to May 2021, 41,140 women were tested for HPV infection. HPV genotyping included 15 high-risk HPV (HR-HPV) and 6 low-risk HPV (LR-HPV) genotypes. Total prevalence, annual trend, and specific age group prevalence and genotype distribution were analyzed.
The overall HPV infection rate was 18.10% among Guangxi women self-referred to clinic for gynecologic problems in southern China. During 2016-2018, the prevalence of HPV infection showed an upward trend, from 18.21% in 2016 to 21.99% in 2018, and later it showed a downward trend, from 18.35% in 2019 to 12.26% in May 2021. Pure HR-HPV genotypes (14.36%) were found in more infections than pure LR-HPV genotypes (2.77%) and mixed genotypes (0.97%). Two peaks of HPV infection were found in the ≤ 25 years (22.94%) and 56-65 years (21.25%) groups. The six most prevalent HR-HPV genotypes were HPV 52 (4.06%), 16 (2.70%), 58 (2.24%), 51 (1.87%), 39 (1.52%), and 53 (1.52%). The three most prevalent LR-HPV genotypes were HPV 6 (1.31%), CP8304 (1.01%), and 11 (0.82%). Infection with a single HR-HPV genotype was the most common type of infection, with an overall infection rate of 12.30%. Infection with two HPV genotypes was the most common multiple HR-HPV infection type, with an infection rate of 2.35%.
The cervical HPV infection rate of women in Guangxi is very high, and there is significant age specificity. There is a need to increase HPV vaccination of young people and the screening of middle-aged and elderly people.
人乳头瘤病毒是宫颈癌和尖锐湿疣的主要病因。人乳头瘤病毒疫苗可预防高级别宫颈病变以及宫颈癌。本研究旨在分析在中国批准使用人乳头瘤病毒疫苗前后广西女性中人乳头瘤病毒的流行情况和基因型分布。
2016年1月至2021年5月，对41140名女性进行了人乳头瘤病毒感染检测。人乳头瘤病毒基因分型包括15种高危人乳头瘤病毒（HR-HPV）和6种低危人乳头瘤病毒（LR-HPV）基因型。分析了总体流行率、年度趋势以及特定年龄组的流行率和基因型分布。
在中国南方因妇科问题自行前往诊所就诊的广西女性中，总体人乳头瘤病毒感染率为18.10%。2016-2018年期间，人乳头瘤病毒感染率呈上升趋势，从2016年的18.21%升至2018年的21.99%，随后呈下降趋势，从2019年的18.35%降至2021年5月的12.26%。纯HR-HPV基因型感染（14.36%）比纯LR-HPV基因型感染（2.77%）和混合基因型感染（0.97%）更为常见。在≤25岁组（22.94%）和56-65岁组（21.25%）中发现了两个人乳头瘤病毒感染高峰。六种最常见的HR-HPV基因型为HPV 52（4.06%）、16（2.70%）、58（2.24%）、51（1.87%）、39（1.52%）和53（1.52%）。三种最常见的LR-HPV基因型为HPV 6（1.31%）、CP8304（1.01%）和11（0.82%）。单一HR-HPV基因型感染是最常见的感染类型，总体感染率为12.30%。两种人乳头瘤病毒基因型感染是最常见的多重HR-HPV感染类型，感染率为2.35%。
广西女性宫颈人乳头瘤病毒感染率很高，且存在显著的年龄特异性。有必要增加年轻人的人乳头瘤病毒疫苗接种以及中老年人的筛查。
