Department of Pharmacology, College of Medicine, Prince Sultan Cardiac Center, Qassim University, Buraydah, Qassim, Saudi Arabia.
College of Medicine, Qassim University, Buraydah, Qassim, Saudi Arabia.
Cardiovasc Hematol Agents Med Chem. 2024;22(4):503-507. doi: 10.2174/0118715257252349231018151957.
Beta-blockers are essential agents in the management of cardiovascular diseases, such as heart failure, acute myocardial infarction (MI), and cardiac arrhythmias. However, there are diurnal variations in the cardioprotective effects of the subgroups as a result of their different pharmacokinetic, pharmacodynamic, and pharmacogenetic profiles.
We aimed to compare metoprolol and bisoprolol in terms of electrocardiogram (ECG) outcomes.
A retrospective cross-sectional study was conducted at Prince Sultan Cardiac Center. The trial included 404 patients who met the inclusion criteria (204 in the metoprolol arm and 200 in the bisoprolol arm). Using case record forms that had already been created, information, such as patient demographics, medical histories, and treatment histories, was taken from their medical files. The most recent ECG records were also gathered. The ethical approval for this study was obtained from Qassim ethical committee (approval number: 45-44-902).
There was no significant difference found between the patients in both arms in terms of baseline characteristics, age, or sex.
In this retrospective cross-sectional study, we have compared the effects of metoprolol and bisoprolol beta blockers on ECG changes. The findings have indicated no difference between metoprolol and bisoprolol groups in terms of all ECG readings, particularly PR/ms, QTC-ms, and ventricular rate. Further studies are required to confirm these findings.
β受体阻滞剂是心力衰竭、急性心肌梗死（MI）和心律失常等心血管疾病管理的重要药物。然而，由于其药代动力学、药效学和药代遗传学特征不同，亚组的心脏保护作用存在昼夜变化。
我们旨在比较美托洛尔和比索洛尔在心电图（ECG）结果方面的差异。
这是在王子苏丹心脏中心进行的一项回顾性横断面研究。该试验纳入了符合纳入标准的 404 名患者（美托洛尔组 204 名，比索洛尔组 200 名）。通过使用已经创建的病例记录表格，从他们的医疗档案中获取患者人口统计学、病史和治疗史等信息。还收集了最近的心电图记录。本研究获得了卡西姆伦理委员会的伦理批准（批准号：45-44-902）。
两组患者在基线特征、年龄或性别方面无显著差异。
在这项回顾性横断面研究中，我们比较了美托洛尔和比索洛尔β受体阻滞剂对心电图变化的影响。研究结果表明，在所有心电图读数，特别是 PR/ms、QTC-ms 和心室率方面，美托洛尔组和比索洛尔组之间没有差异。需要进一步的研究来证实这些发现。
