Crosson B, Parker J C, Kim A K, Warren R L, Kepes J J, Tully R
Brain Lang. 1986 Nov;29(2):301-14. doi: 10.1016/0093-934x(86)90050-7.
This study discusses a case of aphasia after dominant thalamic lesion, a hemorrhagic infarction. Unlike other such cases, both repeated standardized assessment and postmortem verification were available. The patient was assessed at 3 weeks and again at 9 weeks postonset. The aphasia demonstrated the syndrome common to dominant thalamic hemorrhage: fluent but paraphasic output sometimes deteriorating to jargon, comprehension less impaired than this type of output usually indicates, and the least impairment in repetition. As sometimes reported in previous cases, semantic paraphasias were more common than phonemic paraphasias. The lesion was located in the dorsal aspect of the lateral nucleus, but it extended into the pulvinar, including the anterior superior lateral aspect which has been implicated in language by previous studies. Thus, data from this case are consistent with an involvement of the dominant pulvinar in language and suggest that this role involves the semantic aspects of language.
本研究讨论了一例因优势丘脑病变（出血性梗死）导致的失语症。与其他此类病例不同的是，该病例既有重复的标准化评估，又有尸检验证。患者在发病后3周和9周时接受了评估。失语症表现出优势丘脑出血常见的综合征：言语流畅但存在错语，有时会恶化为杂乱语，理解能力受损程度低于这种言语输出通常所提示的情况，且复述能力受损最小。正如之前病例中有时所报道的那样，语义性错语比音素性错语更为常见。病变位于外侧核的背侧，但延伸至枕叶，包括先前研究认为与语言有关的前上外侧部分。因此，该病例的数据与优势枕叶参与语言功能一致，并表明这一作用涉及语言的语义方面。
