Ming Cheng, Bai Xuelian, Zhao Lifeng, Yu Dedong, Wang Xiaomin, Wu Yun
Department of Oncology, Baotou Central Hospital, Inner Mongolia Medical University, Baotou, China.
Department of Oncology, Baotou Central Hospital, Baotou, China.
Front Oncol. 2023 Oct 18;13:1131803. doi: 10.3389/fonc.2023.1131803. eCollection 2023.
Cervical carcinoma (CC) is the one of most common gynecologic cancers worldwide. The ribosomal proteins (RPs) are essential for ribosome assembly and function, and it has been verified that the abnormal expression of RPs was closely associated with tumorigenesis. In this study, we found that the RP large subunit 24 (RPL24) expression level was upregulated after the CC cell lines SiHa and HeLa were treated with Cisplatin (CDDP) . Simultaneously, a nude mouse xenograft model was used to examine the effect of RPL24 on tumor growth , which showed that overexpression of RPL24 can suppress tumor growth. Furthermore, we proved that RPL24 expression increased after CC patients were treated with concurrent chemoradiotherapy (CCRT), and the higher expression of RPL24 predicted a better prognosis using clinical data from 40 CC patients, verified via the Kaplan-Meier Plotter and LOGpc. These results revealed that RPL24 can be considered a potential biomarker to predict the prognosis of CC patients and assess CCRT efficacy.
宫颈癌（CC）是全球最常见的妇科癌症之一。核糖体蛋白（RPs）对于核糖体的组装和功能至关重要，并且已经证实RPs的异常表达与肿瘤发生密切相关。在本研究中，我们发现用顺铂（CDDP）处理CC细胞系SiHa和HeLa后，核糖体蛋白大亚基24（RPL24）的表达水平上调。同时，使用裸鼠异种移植模型来检测RPL24对肿瘤生长的影响，结果显示RPL24的过表达可抑制肿瘤生长。此外，我们通过40例CC患者的临床数据证明，CC患者接受同步放化疗（CCRT）后RPL24表达增加，并且RPL24的较高表达预示着更好的预后，这通过Kaplan-Meier Plotter和LOGpc得到验证。这些结果表明，RPL24可被视为预测CC患者预后和评估CCRT疗效的潜在生物标志物。
