Shiraz Neuroscience Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Tehran, Iran.
Hum Cell. 2024 Jan;37(1):139-153. doi: 10.1007/s13577-023-00996-2. Epub 2023 Nov 4.
According to the findings of recent research, Helicobacter Pylori (H. pylori) infection is not only the primary cause of gastric cancer (GC), but it is also linked to the spread and invasion of GC through a number of processes and factors that contribute to virulence. In this study, we discussed that H. pylori infection can increase autophagy in GC tumor cells, leading to poor prognosis in such patients. Until now, the main concerns have been focused on H. pylori's role in GC development. According to our hypothesis, however, H. pylori infection may also lead to GC dormancy, metastasis, and recurrence by stimulating autophagy. Therefore, understanding how H. pylori possess these processes through its virulence factors and various microRNAs can open new windows for providing new prevention and/or therapeutic approaches to combat GC dormancy, metastasis, and recurrence which can occur in GC patients with H. pylori infection with targeting autophagy and eradicating H. pylori infection.
根据最近的研究结果，幽门螺杆菌（H. pylori）感染不仅是胃癌（GC）的主要原因，而且还通过多种促进毒力的过程和因素与 GC 的传播和侵袭有关。在本研究中，我们讨论了 H. pylori 感染可增加 GC 肿瘤细胞中的自噬，从而导致此类患者预后不良。到目前为止，主要关注点一直集中在 H. pylori 在 GC 发展中的作用。然而，根据我们的假设，H. pylori 感染也可能通过刺激自噬导致 GC 休眠、转移和复发。因此，了解 H. pylori 通过其毒力因子和各种 microRNAs 具有这些过程，可以为通过靶向自噬和根除 H. pylori 感染来预防和/或治疗 GC 休眠、转移和复发提供新的方法，这些方法可能会发生在感染 H. pylori 的 GC 患者中。
