东非成年人群中糖尿病前期的患病率及相关因素：一项系统评价和荟萃分析。

Prevalence and associated factors of prediabetes in adult East African population: A systematic review and meta-analysis.

作者信息

Asmelash Daniel, Mesfin Bambo Getachew, Sahile Samuel, Asmelash Yemane

机构信息

Department of Medical Laboratory Science, College of Medicine and Health Sciences, Mizan-Tepi University, Mizan-Aman, Ethiopia.

Department of Statistics, College of Natural and Computational Science, Aksum University, Aksum, Ethiopia.

出版信息

Heliyon. 2023 Oct 20;9(11):e21286. doi: 10.1016/j.heliyon.2023.e21286. eCollection 2023 Nov.

DOI:10.1016/j.heliyon.2023.e21286

PMID:37928032

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10623273/

Abstract

INTRODUCTION

Diabetes mellitus is a major public health problem with serious consequences, and more than three-fourths of diabetes live in low- and middle-income countries. According to a recent study, people with prediabetes have nearly six times the risk of developing diabetes than those with normal glucose levels. However, due to the inconsistency and absence of representative data, this study aimed to estimate the prevalence of prediabetes and its associated factors in the adult East African population.

METHODS

Databases were systematically searched for articles published between January 1, 2013, and December 30, 2022. All observational community-based studies that reported prediabetes prevalence and/or associated factors in adult East African populations were included in the meta-analyses. Three authors independently extracted all required data using the Excel data extraction format and analyzed using Stata™ Version 11. An I2 test was conducted to determine significant heterogeneity. Finally, a random effects model was used to determine the overall prevalence of prediabetes and its associated factors. The study was registered with Prospero number CRD42023389745.

RESULTS

The search strategy identified 267 articles. After screening for full-text review, twenty-one articles were included in the final analysis. The overall prevalence of prediabetes was 12.58 % (95 % CI:10.30, 14.86 %) in the adult East African population. Furthermore, the subgroup analysis revealed that prediabetes in the urban population 20 % (95 % CI: 1.60, 38.37) was twice as prevalent as in rural 10.0 % (95 % CI: 5.52, 14.48) populations. The prevalence of prediabetes by the ADA diagnostic criteria was 21.45 % (95 % CI: 15.54, 27.35) three times higher than the WHO 7.20 % (95 % CI: 5.70, 8.69). Moreover, prediabetes was significantly associated with old age (OR = 1.64, 95 %, CI: 1.07, 2.53), hypertension (OR = 2.43, 95 %, CI: 1.02-5.79), obesity and overweight (OR = 1.70, 95 %, CI: 1.09,2.65).

CONCLUSION

This study showed a high prevalence of prediabetes, which was significantly associated with old age, hypertension, and high BMI. This study suggests that health policymakers should pay attention to the prevention and control strategies that is targeted at those with obesity, hypertension, and old age.

摘要

引言

糖尿病是一个具有严重后果的重大公共卫生问题，超过四分之三的糖尿病患者生活在低收入和中等收入国家。根据最近的一项研究，糖尿病前期患者患糖尿病的风险是血糖水平正常者的近六倍。然而，由于数据的不一致性和缺乏代表性，本研究旨在估计东非成年人群中糖尿病前期的患病率及其相关因素。

方法

系统检索2013年1月1日至2022年12月30日期间发表的文章数据库。所有报告东非成年人群中糖尿病前期患病率和/或相关因素的基于社区的观察性研究均纳入荟萃分析。三位作者使用Excel数据提取格式独立提取所有所需数据，并使用Stata™ 11版本进行分析。进行I²检验以确定显著异质性。最后，使用随机效应模型确定糖尿病前期的总体患病率及其相关因素。该研究已在国际前瞻性系统评价注册库（Prospero）注册，注册号为CRD42023389745。

结果

检索策略共识别出267篇文章。经过全文筛选，最终纳入21篇文章进行分析。东非成年人群中糖尿病前期的总体患病率为12.58%（95%置信区间：10.30，14.86%）。此外，亚组分析显示，城市人群中糖尿病前期患病率为20%（95%置信区间：1.60，38.37），是农村人群中10.0%（95%置信区间：5.52，14.48）的两倍。根据美国糖尿病协会（ADA）诊断标准，糖尿病前期患病率为21.45%（95%置信区间：15.54，27.35），是世界卫生组织（WHO）标准下7.20%（95%置信区间：5.70，8.69）的三倍。此外，糖尿病前期与老年（比值比[OR]=1.64，95%置信区间：1.07，2.53）、高血压（OR=2.43，95%置信区间：1.02 - 5.79）、肥胖和超重（OR=1.70，95%置信区间：1.09，2.65）显著相关。