School of Medicine, Alimentary Tract Research Center, Clinical Sciences Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Nutrition and Metabolic Diseases Research Center, Clinical Sciences Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
BMC Endocr Disord. 2022 Mar 19;22(1):72. doi: 10.1186/s12902-022-00990-z.
Increasing trend of prediabetes and diabetes is a global public health issue. On the other hand, prediabetes can increase the risk of developing some non-communicable diseases, including type 2 diabetes, cardiovascular disease, hypertension, fatty liver disease, etc. Given that there are modifiable various risk factors for prediabetes, this cross-sectional study aimed to evaluate the prevalence of prediabetes and its risk factors among adults.
The present study included the baseline data from the Prospective Epidemiological Research Studies of the Iranian Adult and Neonates (PERSIAN), Hoveyzeh Cohort Study (N = 10,009). The demographic data, lifestyle habits, anthropometric data, and clinical and biochemical parameters were gathered. The odds ratio of prediabetes was assessed by logistic regression.
The final analysis was conducted on 7629 participants. The prevalence of overweight (36.7%), obesity (37.5%), prediabetes (30.29%), abnormal high density lipoprotein (35.4%), cholesterol (33.8%) and triglyceride (39.7%), and HTN (21.3%) were common. In the adjusted analysis, there were higher odds of having prediabetes for overweight (OR = 1.9, 95% CI: (1.19, 3.03), p = 0.007), obesity (OR = 3.18, 95% CI: (1.99, 5.07), p < 0.001), waist circumstance (WC) (OR = 1.024, 95% CI: (1.002, 1.03), p < 0.001), hip circumstance (HC) (OR = 1.01, 95% CI: (1.003, 1.02), p = 0.008), older age (OR = 1.04, 95% CI: (1.04, 1.05), p < 0.001), hypertension (OR = 1.38, 95% CI: (1.21, 1.57), p < 0.001),), glutamic-pyruvic transaminase (OR = 1.013, 95% CI: (1.007, 1.019), p = 0.001), glutamic-oxaloacetic transaminase (OR = 1.01, 95% CI: (1.006, 1.013), p < 0.001), triglyceride = 150-199 mg/dl (OR = 1.32, 95% CI: (1.16, 1.51), p < 0.001), triglyceride ≥ 200 mg/dl (OR = 1.64 (95% CI: 1.44, 1.86), p < 0.001), cholesterol = 200- 239 mg/dl (OR = 1.33, 95% CI: (1.18, 1.49), p < 0.001), and cholesterol ≥ 240 mg/dl (OR = 2.04, 95% CI: (1.72, 2.42), p < 0.001) in general population.
The prevalence of prediabetes, overweight, obesity, HTN, and dyslipidemia was common. The greater chances of prediabetes were related to aging, overweight, obesity, HTN, higher liver enzymes, HC, abnormal WC, and dyslipidemia. It seems that practical interventions are necessary to prevent prediabetes.
糖尿病前期和糖尿病发病率呈上升趋势，这是一个全球性的公共卫生问题。另一方面，糖尿病前期会增加患 2 型糖尿病、心血管疾病、高血压、脂肪肝等多种非传染性疾病的风险。鉴于糖尿病前期有多种可改变的危险因素，本横断面研究旨在评估成年人中糖尿病前期的患病率及其危险因素。
本研究纳入了伊朗成人和新生儿前瞻性流行病学研究（PERSIAN）、霍韦泽赫队列研究（N=10009）的基线数据。收集了人口统计学数据、生活方式习惯、人体测量学数据以及临床和生化参数。采用 logistic 回归评估糖尿病前期的比值比。
最终对 7629 名参与者进行了分析。超重（36.7%）、肥胖（37.5%）、糖尿病前期（30.29%）、异常高密度脂蛋白（35.4%）、胆固醇（33.8%）和甘油三酯（39.7%）以及高血压（21.3%）的患病率较高。在调整分析中，超重（OR=1.9，95%CI：（1.19，3.03），p=0.007）、肥胖（OR=3.18，95%CI：（1.99，5.07），p<0.001）、腰围（WC）（OR=1.024，95%CI：（1.002，1.03），p<0.001）、臀围（HC）（OR=1.01，95%CI：（1.003，1.02），p=0.008）、年龄较大（OR=1.04，95%CI：（1.04，1.05），p<0.001）、高血压（OR=1.38，95%CI：（1.21，1.57），p<0.001）、谷草转氨酶（AST）（OR=1.013，95%CI：（1.007，1.019），p=0.001）、谷丙转氨酶（ALT）（OR=1.01，95%CI：（1.006，1.013），p<0.001）、甘油三酯 150-199mg/dl（OR=1.32，95%CI：（1.16，1.51），p<0.001）、甘油三酯≥200mg/dl（OR=1.64（95%CI：1.44，1.86），p<0.001）、胆固醇 200-239mg/dl（OR=1.33，95%CI：（1.18，1.49），p<0.001）和胆固醇≥240mg/dl（OR=2.04，95%CI：（1.72，2.42），p<0.001）的糖尿病前期发生几率更高。
糖尿病前期、超重、肥胖、高血压和血脂异常的患病率较高。糖尿病前期的发病几率更高与年龄增长、超重、肥胖、高血压、肝酶升高、HC、异常 WC 和血脂异常有关。看来有必要采取切实可行的干预措施来预防糖尿病前期。
