Department of Microbiology, Immunology, and Cancer Biology, University of Virginia School of Medicine, Charlottesville, VA.
J Immunol. 2023 Nov 15;211(10):1443-1449. doi: 10.4049/jimmunol.2300333.
C4b-binding protein (C4BP) is a fluid-phase complement inhibitor that prevents uncontrolled activation of the classical and lectin complement pathways. As a complement inhibitor, C4BP also promotes apoptotic cell death and is hijacked by microbes and tumors for complement evasion. Although initially characterized for its role in complement inhibition, there is an emerging recognition that C4BP functions in a complement-independent manner to promote cell survival, protect against autoimmune damage, and modulate the virulence of microbial pathogens. In this Brief Review, we summarize the structure and functions of human C4BP, with a special focus on activities that extend beyond the canonical role of C4BP in complement inhibition.
C4 结合蛋白（C4BP）是一种体液补体抑制剂，可防止经典和凝集素补体途径的失控激活。作为补体抑制剂，C4BP 还促进细胞凋亡，并被微生物和肿瘤劫持以逃避补体。尽管最初的特征是其在补体抑制中的作用，但人们越来越认识到 C4BP 以补体非依赖的方式发挥作用，以促进细胞存活、防止自身免疫损伤，并调节微生物病原体的毒力。在这篇简要综述中，我们总结了人 C4BP 的结构和功能，特别关注超出 C4BP 在补体抑制中的典型作用的活性。
