Tiefenbach B, Lange P
Arch Toxicol Suppl. 1980;4:167-70. doi: 10.1007/978-3-642-67729-8_37.
The actions of the organophosphorous insecticide dimethoate (0.0-dimethyl S-(N-methylcarbamoylmethyl)phosphorodiothioate) on the immune response of mice and rats were studied. There was a decrease of lymphocytes to at 50% of normal. The weights of the thymus and spleen were diminished and the production of antibodies was reduced. 72 h after administration all the parameters measured had returned to normal. Histological examinations show a reduction of the cortex of the thymus and disruption of the thymocytes. The number of rosettes forming cells in rats was reduced after dimethoate. The actions seen after dimethoate administration are identical with the effects observed after glucocorticoid application. These results suggest an indirect depression of the immune system by dimethoate producing a release of glococorticoids.
研究了有机磷杀虫剂乐果（0,0-二甲基-S-（N-甲基氨基甲酰甲基）二硫代磷酸酯）对小鼠和大鼠免疫反应的影响。淋巴细胞数量减少至正常水平的50%。胸腺和脾脏重量减轻，抗体产生减少。给药72小时后，所有测量参数均恢复正常。组织学检查显示胸腺皮质减少，胸腺细胞受到破坏。乐果处理后大鼠中形成玫瑰花结的细胞数量减少。乐果给药后出现的作用与应用糖皮质激素后观察到的效果相同。这些结果表明乐果通过产生糖皮质激素释放而间接抑制免疫系统。
