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外源性透明质酸对脱细胞真皮基质联合薄中厚皮片移植后质量影响的基础与临床研究。

Basic and clinical study of the effect of exogenous hyaluronic acid on the quality of acellular dermal matrix combined with thin intermediate split thickness skin graft.

机构信息

Comprehensive ward, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100144, China.

Department of Burn and Plastic Surgery, Fourth Medical Center of Chinese, Burns Institute, Burn & Plastic Hospital of Chinese PLA General Hospital, PLA General Hospital, Beijing, 100048, China.

出版信息

Eur J Med Res. 2023 Nov 6;28(1):486. doi: 10.1186/s40001-023-01283-4.

DOI:10.1186/s40001-023-01283-4
PMID:37932853
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10626683/
Abstract

BACKGROUND

To promote wound recovery in the recipient region, we studied the impact of exogenous hyaluronic acid (HA) on acellular dermal matrix (ADM) paired with thin intermediate-thickness skin transplant.

METHODS

This study contains animal and clinical experiments. 50 Japanese big ear rabbits were separated into HA1, HA2, PADM, TS, and NS groups. Clinical part included 50 scar patients dividing into 5 groups (TS + HA + ADM 1, TS + ADM2, TS, TS + ADM and normal skin (NS)).

RESULTS

In the animal trial, after 56 days, the grafts contracted least in the HA2 group; HA2 had the highest microvascular density (MVD), HA concentration, and collagen I and III expression. In clinical work, ADM > HA + ADM2 > HA + ADM1 > TS > NS; Type I and III collagen: HA + ADM1 and HA + ADM2 were higher than ADM; HA content: TS > HA + ADM1 > HA + ADM 2 > ADM.

CONCLUSIONS

ADM, exogenous hyaluronic acid mixed with thin skin autograft has better biomechanical qualities and therapeutic impact than acellular dermal matrix alone, and the reconstructive result is near to self-thick skin autograft in all indexes.

摘要

背景

为促进受区创面愈合，我们研究了外源性透明质酸（HA）对脱细胞真皮基质（ADM）联合薄中厚皮片移植的影响。

方法

本研究包含动物实验和临床实验。50 只日本大耳兔分为 HA1、HA2、PADM、TS 和 NS 组。临床部分包括 50 例瘢痕患者，分为 5 组（TS+HA+ADM1、TS+ADM2、TS、TS+ADM 和正常皮肤（NS））。

结果

在动物试验中，56 天后 HA2 组移植皮片收缩最少；HA2 组微血管密度（MVD）最高，HA 浓度及胶原 I、III 表达最高。在临床工作中，ADM＞HA+ADM2＞HA+ADM1＞TS＞NS；I 型和 III 型胶原：HA+ADM1 和 HA+ADM2 高于 ADM；HA 含量：TS＞HA+ADM1＞HA+ADM2＞ADM。

结论

ADM 联合外源性透明质酸与薄中厚皮片自体移植具有比单纯脱细胞真皮基质更好的生物力学特性和治疗效果，在所有指标上的重建效果均接近自体厚皮片。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3cf7/10626683/153ef587bd1e/40001_2023_1283_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3cf7/10626683/fabf5a819267/40001_2023_1283_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3cf7/10626683/374096507f5b/40001_2023_1283_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3cf7/10626683/2b03b9976f7b/40001_2023_1283_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3cf7/10626683/c96082041223/40001_2023_1283_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3cf7/10626683/fe5778941e46/40001_2023_1283_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3cf7/10626683/2b4ff3fcf45e/40001_2023_1283_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3cf7/10626683/7bf006ea4e69/40001_2023_1283_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3cf7/10626683/22c44189740a/40001_2023_1283_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3cf7/10626683/153ef587bd1e/40001_2023_1283_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3cf7/10626683/fabf5a819267/40001_2023_1283_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3cf7/10626683/374096507f5b/40001_2023_1283_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3cf7/10626683/2b03b9976f7b/40001_2023_1283_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3cf7/10626683/c96082041223/40001_2023_1283_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3cf7/10626683/fe5778941e46/40001_2023_1283_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3cf7/10626683/2b4ff3fcf45e/40001_2023_1283_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3cf7/10626683/7bf006ea4e69/40001_2023_1283_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3cf7/10626683/22c44189740a/40001_2023_1283_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3cf7/10626683/153ef587bd1e/40001_2023_1283_Fig9_HTML.jpg

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