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国家提供者调查:纳曲酮在患有物质使用障碍的孕妇中的使用。

National Provider Survey: Use of Naltrexone for Pregnant Individuals with Substance Use Disorders.

机构信息

From the Department of Pediatrics, Boston Medical Center, Boston, MA (CD, NI, JOB, EMW); Boston University School of Public Health, Boston, MA (VG); Boston University Chobanian and Avedisian School of Medicine, Boston, MA (JH, AC); UNC Horizons and Department of Obstetrics and Gynecology, School of Medicine, University of North Carolina at Chapel Hill, Carrboro, NC (GC, HEJ); and Department of Obstetrics and Gynecology, Boston Medical Center, Boston, MA (KAS).

出版信息

J Addict Med. 2023;17(6):736-738. doi: 10.1097/ADM.0000000000001225. Epub 2023 Sep 20.

Abstract

OBJECTIVES

A national survey evaluated the availability of naltrexone as a treatment for alcohol use disorder and/or opioid use disorder for pregnant individuals. Provider perceptions of barriers to treatment with naltrexone during pregnancy were also examined.

METHODS

Sites were selected from a national registry of naltrexone prescribers (N = 5208). A 10% sampling of sites within 150 miles of each state's capital was selected (n = 2073). Survey of 11 questions included availability of naltrexone for pregnant individuals, standard practices for treating pregnant individuals already on naltrexone, and barriers to treatment. Survey responses were summarized to identify top barriers and national trends in service availability.

RESULTS

Of the 236 sites contacted, 78 (33.1%) completed the survey. There was significant geographic variation in number of available sites, with Northeast United States having the most sites. Of the 78 responding sites, only 23 (35.9%) offered naltrexone for pregnant individuals. The most common barriers to prescribing naltrexone included the following: sites without pregnant patients (15.6%), lack of national guidelines in using naltrexone for pregnant patients (14.1%), providers' discomfort with prescribing naltrexone during pregnancy due to safety concerns (9.4%), and providers' discomfort due to inexperience (4.7%).

CONCLUSIONS

Accessibility of naltrexone and related care for pregnant individuals with alcohol use disorder and opioid use disorder varies greatly across the United States with numerous barriers and educational gaps identified. Additional research and resources are needed to expand naltrexone treatment access for pregnant individuals.

摘要

目的

一项全国性调查评估了纳曲酮作为治疗怀孕个体酒精使用障碍和/或阿片类药物使用障碍的可用性。还研究了提供者在怀孕期间使用纳曲酮治疗的障碍。

方法

从纳曲酮处方者全国登记处(N = 5208)中选择了地点。从每个州首府周围 150 英里内选择了 10%的地点样本(n = 2073)。调查了 11 个问题,包括纳曲酮对怀孕个体的可用性、对已经使用纳曲酮的怀孕个体的标准治疗方法以及治疗障碍。总结调查结果,以确定服务可用性的主要障碍和全国趋势。

结果

在联系的 236 个地点中,有 78 个(33.1%)完成了调查。可获得的地点数量存在显著的地域差异,美国东北部拥有最多的地点。在 78 个回应的地点中,只有 23 个(35.9%)为怀孕个体提供纳曲酮。开处方纳曲酮最常见的障碍包括以下几点:无怀孕患者的地点(15.6%)、缺乏使用纳曲酮治疗怀孕患者的国家指南(14.1%)、由于安全问题,提供者在怀孕期间开纳曲酮处方感到不适(9.4%)以及由于缺乏经验,提供者感到不适(4.7%)。

结论

美国各地纳曲酮及其相关护理在怀孕个体酒精使用障碍和阿片类药物使用障碍方面的可及性差异很大,发现了许多障碍和教育差距。需要进一步研究和资源来扩大怀孕个体的纳曲酮治疗机会。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/76c7/10873530/36a3cd95d519/nihms-1924535-f0001.jpg

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Use of naltrexone in treating opioid use disorder in pregnancy.纳曲酮在治疗妊娠期阿片类药物使用障碍中的应用。
Am J Obstet Gynecol. 2020 Jan;222(1):83.e1-83.e8. doi: 10.1016/j.ajog.2019.07.037. Epub 2019 Jul 31.

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