Functional Molecules Analysis and Biotransformation Key Laboratory of Universities in Yunnan Province, School of Chemical Science and Technology, Yunnan University, Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Kunming, 650091, PR China.
College of Chemistry and Environmental Science, Qujing Normal University, Qujing, 655011, PR China.
Nat Prod Res. 2021 Mar;35(5):763-769. doi: 10.1080/14786419.2019.1608542. Epub 2019 May 10.
A new dibenzopyrrocoline alkaloid, (-)-grandifloramine (), together with five known ones, actinodaphnine (), -methyllaurotetanine (), boldine (), lindcarpine (), and (+)-norboldine (), were isolated from W. W. Sm. et J. F. Jeff. The structure of was identified by HRESIMS, 1D/2D NMR, and electronic circular dichroism (ECD) spectra. Compound and exhibited the moderate inhibitory activity against acetylcholinesterase and showed moderate butyrylcholinesterase inhibitory activity. This is the first report of the chemical constituents of .
一种新的二苯并吡咯烷生物碱，（-）大花胺（），与五种已知的化合物一起，如 actinodaphnine（）、-methyllaurotetanine（）、boldine（）、lindcarpine（）和（+）-norboldine（），从 W. W. Sm. et J. F. Jeff. 中分离得到。通过高分辨率质谱（HRESIMS）、1D/2D NMR 和电子圆二色性（ECD）光谱确定了的结构。化合物和表现出对乙酰胆碱酯酶的中等抑制活性，而表现出对丁酰胆碱酯酶的中等抑制活性。这是对的化学成分的首次报道。
