Wang Nan, Chen Shuang, Zhang Xiaoyu, Xi Zhipeng, Fang Xiaoyang, Xue Congyang, Li Jingchi, Xie Lin
Department of Spine Surgery, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, China.
Front Pharmacol. 2022 Aug 8;13:873177. doi: 10.3389/fphar.2022.873177. eCollection 2022.
Stem cells (SCs) therapy for intervertebral disc degeneration (IDD) has been studied for nearly 20 years and it is an important part of regenerative medicine and tissue engineering research, as well as a current research hotspot and challenge. Although the volume of literature has shown an annual growth trend, there is no literature available for bibliometric and clinical analysis of the content of multiple databases in this field. The articles were obtained from the WOSCC, Scopus, Pubmed, and ClinicalTrials on 27 December 2021. Three scientometric software (VOSviewer 1.6.17, CiteSpace 5.8.R.1 and Scimago Graphica) were used to perform bibliometric and knowledge-map analysis. We included 867 articles from WOSCC, 716 articles from Scopus and 6 clinical studies from ClinicalTrials for literature analysis. Our results showed that China was the country with the highest number of publications, with the United States (US) being the leader in terms of international collaborations and the number of citations. Sakai D, Grad S and Hoyland JA had made outstanding contributions for their high productivity and the quality articles. was the most published and most cited journal, in addition to and , which were also more authoritative journals and had received high citations. All of them had received high citations. Keyword co-occurrence studies suggested that the current hotspots were in mechanistic studies, including inflammation, apoptosis, exosome, autophagy, and others. Some studies had also investigated tissue-engineered scaffolds of SCs to better repair degenerated discs. Clinical studies were relatively scarce. Direct injection of Mesenchymal Stem Cells (MSCs) into degenerated discs for the treatment of Degenerative disc disease (DDD) was the current direction of research. This study demonstrates the global research hotspots, trends and clinical use of SCs in the treatment of IDD. It can help scholars to quickly understand the current status and hotspots of research in this field, and also provide some guidance and reference for those who are currently researching in this area.
干细胞疗法治疗椎间盘退变（IDD）的研究已近20年，它是再生医学和组织工程研究的重要组成部分，也是当前的研究热点和挑战。尽管文献数量呈逐年增长趋势，但尚无文献对该领域多个数据库的内容进行文献计量学和临床分析。这些文章于2021年12月27日从Web of Science核心合集（WOSCC）、Scopus、PubMed和ClinicalTrials获取。使用三款科学计量软件（VOSviewer 1.6.17、CiteSpace 5.8.R.1和Scimago Graphica）进行文献计量学和知识图谱分析。我们纳入了来自WOSCC的867篇文章、来自Scopus的716篇文章以及来自ClinicalTrials的6项临床研究进行文献分析。我们的结果表明，中国是发文量最多的国家，美国在国际合作和被引次数方面领先。酒井D、格拉德S和霍伊兰JA因其高产和高质量文章做出了杰出贡献。《脊柱》是发表量和被引次数最多的期刊，此外，《骨与关节外科杂志》和《欧洲脊柱杂志》也是更具权威性的期刊，且被引次数较高。它们都获得了较高的被引次数。关键词共现研究表明，当前的热点在于机制研究，包括炎症、细胞凋亡、外泌体、自噬等。一些研究还对干细胞的组织工程支架进行了研究，以更好地修复退变椎间盘。临床研究相对较少。将间充质干细胞（MSCs）直接注射到退变椎间盘中治疗椎间盘退变疾病（DDD）是当前的研究方向。本研究展示了干细胞治疗IDD的全球研究热点、趋势及临床应用。它有助于学者快速了解该领域的研究现状和热点，也为目前在该领域进行研究的人员提供一些指导和参考。
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