Ingram D K, Weindruch R, Spangler E L, Freeman J R, Walford R L
J Gerontol. 1987 Jan;42(1):78-81. doi: 10.1093/geronj/42.1.78.
Female C3B10RF1 mice maintained on either a control (approximately 95 kcal/week) or restricted (approximately 55 kcal/week) diet since weaning were tested in a behavioral battery at 11 to 15 or 31 to 35 months of age (middle-aged vs. aged). Age-related declines observed among control groups in tests of motor coordination (rotorod) and learning (complex maze) were prevented by the restriction regime. In addition, diet restriction increased locomotor activity in a runwheel cage among mice of both ages but did not affect exploratory activity in a novel arena.
自断奶起就维持在对照饮食（约95千卡/周）或限制饮食（约55千卡/周）的雌性C3B10RF1小鼠，在11至15个月龄或31至35个月龄（中年与老年）时接受了一系列行为测试。在运动协调测试（转棒试验）和学习测试（复杂迷宫）中，对照组中观察到的与年龄相关的能力下降被限制饮食方案所预防。此外，饮食限制增加了两个年龄组小鼠在跑步轮笼中的运动活动，但不影响在新环境中的探索活动。
