Department of Neurosurgery, Jiangnan University Medical Center, Wuxi, China.
Wuxi Neurosurgical Institute, Wuxi, China.
Ann Clin Lab Sci. 2023 Sep;53(5):719-725.
To investigate the expression of lncRNA UCA1 in serum of patients with acute cerebral infarction (ACI) and its relationship with prognosis.
The serum lncRNA UCA1 level in participants was detected, and the correlation between the neurological function score (NIHSS score) of ACI patients and lncRNA UCA1 expression was analyzed. Patients were followed up at 3 months after discharge and were divided into favorable and unfavorable prognostic groups according to the modified Rankin scale (mRs). The risk factors of ACI patients with poor prognosis were analyzed, and the predictive value of each index for ACI prognosis was evaluated by ROC curve.
The level of lncRNA UCA1 in ACI group was increased (<0.001). ROC analysis showed that high lncRNA UCA1 expression had clinical significance for the diagnosis of ACI. Spearman correlation analysis revealed that NIHSS score was positively correlated with lncRNA UCA1 expression level in ACI group (r=0.6537, <0.001). Hcy level and NIHSS score in poor prognosis group (n=63) were higher than those in good prognosis group (n=84), and lncRNA UCA1 level in serum in poor prognosis group was increased in comparison to good prognosis group (<0.05). Logistic regression analysis investigated that admission NIHSS score, infarct size, and increased lncRNA UCA1 were the risk factors affecting the prognosis of ACI.
Serum lncRNA UCA1 is abnormally elevated in ACI patients, and the elevated lncRNA UCA1 not only shows high accuracy in the diagnosis of ACI, but also has a certain predictive value for poor prognosis of ACI.
探讨长链非编码 RNA UCA1 在急性脑梗死（ACI）患者血清中的表达及其与预后的关系。
检测研究对象血清 lncRNA UCA1 水平，分析 ACI 患者神经功能评分（NIHSS 评分）与 lncRNA UCA1 表达的相关性。患者出院后进行 3 个月随访，根据改良 Rankin 量表（mRs）分为预后良好组和预后不良组。分析 ACI 患者预后不良的危险因素，通过 ROC 曲线评估各指标对 ACI 预后的预测价值。
ACI 组 lncRNA UCA1 水平升高（<0.001）。ROC 分析表明，高 lncRNA UCA1 表达对 ACI 的诊断具有临床意义。Spearman 相关分析显示，ACI 组 NIHSS 评分与 lncRNA UCA1 表达水平呈正相关（r=0.6537，<0.001）。预后不良组（n=63）的 Hcy 水平和 NIHSS 评分均高于预后良好组（n=84），且预后不良组血清 lncRNA UCA1 水平高于预后良好组（<0.05）。Logistic 回归分析发现，入院 NIHSS 评分、梗死灶大小和 lncRNA UCA1 升高是影响 ACI 预后的危险因素。
ACI 患者血清 lncRNA UCA1 异常升高，升高的 lncRNA UCA1 不仅对 ACI 的诊断具有较高的准确性，而且对 ACI 预后不良具有一定的预测价值。
