Department of Neurology, Inner Mongolia Baogang Hospital, 20 Shaoxian Road, Kunqu District, Baotou 014017, Inner Mongolia, China.
Department of Psychosomatic, Baotou Central Hospital, 61 Huancheng Road, Donghe District, Baotou 014040, Inner Mongolia, China.
Clin Neurol Neurosurg. 2022 Sep;220:107352. doi: 10.1016/j.clineuro.2022.107352. Epub 2022 Jun 25.
The study examined the diagnostic and prognostic value of GST-π combined with CypA in acute cerebral infarction (ACI).
The study included 115 ACI patients and 85 healthy people. Expression patterns of serum GST-π and CypA were detected using ELISA. The diagnostic efficiency of GST-π, CypA, and GST-π combined with CypA on ACI was assessed by ROC curves. Pathological parameters were further analyzed using the Fisher test, t test, and one-way ANOVA. ACI patients were subsequently assigned into severe, moderate, and mild groups under the National Institutes of Health Stroke Scale (NIHSS), followed by Pearson analysis of the correlation between GST-π and CypA and NIHSS scores. The prognosis was evaluated by follow-up using modified Rankin Scale. Correlation between GST-π/CypA expression and ACI prognosis was predicted using a survival curve, and the predictive value of GST-π/CypA on ACI prognosis was assessed with a ROC curve. Lastly, the independent correlation of GST-π and CypA with poor ACI prognosis was analyzed with Logistics multivariate regression analysis.
GST-π and CypA were both highly-expressed in ACI patients. GST-π combined with CypA could better aid ACI diagnosis. Expressions of GST-π and CypA were positively correlated with NIHSS scores of ACI patients. High expressions of GST-π and CypA were correlated with poor short-term prognosis of ACI patients.
Serum GST-π combined with CypA aids diagnosis and predicts poor short-term prognoses of ACI.
The data that support the findings of this study are available from the corresponding author upon reasonable request.
本研究探讨 GST-π 联合 CypA 在急性脑梗死（ACI）中的诊断和预后价值。
本研究纳入 115 例 ACI 患者和 85 名健康对照者。采用 ELISA 法检测血清 GST-π 和 CypA 的表达水平。通过 ROC 曲线评估 GST-π、CypA 及 GST-π 联合 CypA 对 ACI 的诊断效率。采用 Fisher 检验、t 检验和单因素方差分析进一步分析病理参数。根据美国国立卫生研究院卒中量表（NIHSS）将 ACI 患者分为重度、中度和轻度组，然后进行 Pearson 分析 GST-π 和 CypA 与 NIHSS 评分的相关性。采用改良 Rankin 量表进行随访评估预后。采用生存曲线预测 GST-π/CypA 表达与 ACI 预后的相关性，采用 ROC 曲线评估 GST-π/CypA 对 ACI 预后的预测价值。最后，采用 Logistic 多元回归分析分析 GST-π 和 CypA 与 ACI 不良预后的独立相关性。
GST-π 和 CypA 在 ACI 患者中均高表达。GST-π 联合 CypA 可更好地辅助 ACI 诊断。GST-π 和 CypA 的表达与 ACI 患者的 NIHSS 评分呈正相关。GST-π 和 CypA 的高表达与 ACI 患者短期预后不良相关。
血清 GST-π 联合 CypA 有助于 ACI 的诊断和预测短期不良预后。
支持本研究结果的数据可根据合理要求向通讯作者索取。
