Department of Toxicology, School of Public Health, Peking University, Beijing Key Laboratory of Toxicological Research and Risk Assessment for Food Safety, Beijing 100191, China.
Department of Toxicology, School of Public Health, Peking University, Beijing Key Laboratory of Toxicological Research and Risk Assessment for Food Safety, Beijing 100191, China.
Pestic Biochem Physiol. 2023 Nov;196:105640. doi: 10.1016/j.pestbp.2023.105640. Epub 2023 Oct 4.
Plant growth regulators (PGRs) are currently one of the widely used pesticides, as being considered to have relatively low toxicity compared with other pesticides. However, widespread use may lead to overexposure from multiple sources. Exposure to PGRs is associated with different toxicity that affects many organs in our body, such as the toxicity to testis, ovaries, liver, kidneys and brain. In addition, some PGRs are considered potential endocrine disrupting chemicals. Evidence exists for development and reproductive toxicity associated with prenatal and postnatal exposure in both animals and humans. PGRs can affect the synthesis and secretion of sex hormones, destroy the structure and function of the reproductive system, and harm the growth and development of offspring, which may be related to germ cell cycle disorders, apoptosis and oxidative stress. This review summaries the reproductive and developmental toxicity data available about PGRs in mammals. In the future, conducting comprehensive epidemiological studies will be crucial for assessing the reproductive and developmental toxicity resulting from a mixture of various PGRs, with a particular emphasis on understanding the underlying molecular mechanisms.
植物生长调节剂 (PGRs) 是目前广泛使用的农药之一，因其与其他农药相比毒性相对较低。然而，广泛使用可能会导致来自多种来源的过度暴露。暴露于 PGRs 会导致不同的毒性，影响我们体内的许多器官，如对睾丸、卵巢、肝脏、肾脏和大脑的毒性。此外，一些 PGRs 被认为是潜在的内分泌干扰化学物质。有证据表明，在动物和人类中，产前和产后暴露于 PGRs 会导致发育和生殖毒性。PGRs 会影响性激素的合成和分泌，破坏生殖系统的结构和功能，损害后代的生长发育，这可能与生殖细胞周期紊乱、细胞凋亡和氧化应激有关。这篇综述总结了关于哺乳动物中 PGRs 的生殖和发育毒性数据。未来，开展综合的流行病学研究对于评估由各种 PGRs 混合引起的生殖和发育毒性至关重要，特别需要了解潜在的分子机制。
